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肝脏衰老的系统效应

IF 17.3 1区 生物学 Q1 CELL BIOLOGY
Nature Cell Biology Pub Date : 2024-11-13 DOI:10.1038/s41556-024-01520-w
Kuo Du, David Scott Umbaugh, Rajesh Kumar Dutta, Anna Mae Diehl
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引用次数: 0

摘要

一项研究表明，肝脏诱发的衰老可向全身扩散，导致多器官功能障碍。研究发现，TGFβ信号是这种传播的关键介质，这为预防严重肝病的多器官功能衰竭提供了治疗途径。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

A systemic effect for liver senescence

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A systemic effect for liver senescence
A study shows that senescence induced in the liver can spread systemically to precipitate multi-organ dysfunction. The work identifies TGFβ signalling as a key mediator of this transmission, suggesting therapeutic avenues to prevent multi-organ failure in severe liver diseases.
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来源期刊
Nature Cell Biology
Nature Cell Biology 生物-细胞生物学
CiteScore
28.40
自引率
0.90%
发文量
219
审稿时长
3 months
期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology
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