Mx1-ing it up--系统性红斑狼疮单核细胞中干扰素依赖性、非常规 IL-1β 释放的线粒体继电器

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-11-12 DOI:10.1016/j.immuni.2024.10.005

Andrea Dorfleutner, Christian Stehlik, Caroline A. Jefferies

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引用次数: 0

摘要

Ⅰ型干扰素（IFN-I）在系统性红斑狼疮（SLE）中的作用已被充分证明，但白细胞介素（IL）-1β的作用却仍然难以捉摸。在本期《免疫》（Immunity）杂志上，Caielli 等人发现了一个共同产生 IL-1β 和 IFN-I 的系统性红斑狼疮单核细胞群，并描述了含线粒体核酸的红细胞如何参与 cGAS/STING、RIG-I、MDA5 和 NLRP3 以实现非常规的 IL-1β 释放。

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Mx1-ing it up—Mitochondrial relay for interferon-dependent, unconventional IL-1β release in SLE monocytes

The role of type I interferon (IFN-I) in systemic lupus erythematosus (SLE) is well documented, but the role of interleukin (IL)-1β remains elusive. In this issue of Immunity, Caielli et al. identified an SLE monocyte population coproducing IL-1β and IFN-I and described how mitochondrial nucleic-acid-containing RBCs engage cGAS/STING, RIG-I, MDA5, and NLRP3 for unconventional IL-1β release.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.