{"title":"N'-（2-羟基-4-甲氧基亚苄基）-4-硝基苯甲酰肼及其锌（II）络合物的合成、晶体结构和尿素酶抑制作用","authors":"J. Jiang, P. Liang, B. Liu, C. Tang, Z. You","doi":"10.1134/S002247662410007X","DOIUrl":null,"url":null,"abstract":"<p>An aroylhydrazone compound <i>N’</i>-(2-hydroxy-4-methoxybenzylidene)-4-nitrobenzohydrazide (HL) was prepared. Reaction of the aroylhydrazone compound with zinc iodide afforded a dinuclear zinc(II) complex [Zn<sub>2</sub>I<sub>2</sub>L<sub>2</sub>]∙2DMF. The aroylhydrazone compound and the zinc complex were characterized by CHN elemental analyses and infrared spectroscopy. Detailed structures are further confirmed by single crystal X-ray determination. The Zn atom in the complex is in square pyramidal coordination, with the phenolate O, imino N and carbonyl O atoms of one L ligand, and the phenolate O atom of the other L ligand in the basal plane, and with one I ligand at the apical position. The crystal structures of the aroylhydrazone and the zinc complex are stabilized by hydrogen bonds. The two compounds have been tested for their <i>Jack bean</i> urease activity. As a result, the zinc complex has effective activity with <i>IC</i><sub>50</sub> value of 1.7 ± 0.3 μmol/L.</p>","PeriodicalId":668,"journal":{"name":"Journal of Structural Chemistry","volume":"65 10","pages":"1950 - 1960"},"PeriodicalIF":1.2000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, Crystal Structures and Urease Inhibition of N’-(2-Hydroxy-4-Methoxybenzylidene)-4-Nitrobenzohydrazide and its Zinc(II) Complex\",\"authors\":\"J. Jiang, P. Liang, B. Liu, C. Tang, Z. You\",\"doi\":\"10.1134/S002247662410007X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>An aroylhydrazone compound <i>N’</i>-(2-hydroxy-4-methoxybenzylidene)-4-nitrobenzohydrazide (HL) was prepared. Reaction of the aroylhydrazone compound with zinc iodide afforded a dinuclear zinc(II) complex [Zn<sub>2</sub>I<sub>2</sub>L<sub>2</sub>]∙2DMF. The aroylhydrazone compound and the zinc complex were characterized by CHN elemental analyses and infrared spectroscopy. Detailed structures are further confirmed by single crystal X-ray determination. The Zn atom in the complex is in square pyramidal coordination, with the phenolate O, imino N and carbonyl O atoms of one L ligand, and the phenolate O atom of the other L ligand in the basal plane, and with one I ligand at the apical position. The crystal structures of the aroylhydrazone and the zinc complex are stabilized by hydrogen bonds. The two compounds have been tested for their <i>Jack bean</i> urease activity. As a result, the zinc complex has effective activity with <i>IC</i><sub>50</sub> value of 1.7 ± 0.3 μmol/L.</p>\",\"PeriodicalId\":668,\"journal\":{\"name\":\"Journal of Structural Chemistry\",\"volume\":\"65 10\",\"pages\":\"1950 - 1960\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2024-11-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Structural Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S002247662410007X\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Structural Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S002247662410007X","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
摘要
制备了一种甲酰腙化合物 N'-（2-羟基-4-甲氧基亚苄基）-4-硝基苯甲酰肼（HL）。将甲酰基腙化合物与碘化锌反应，可得到双核锌（II）络合物 [Zn2I2L2]∙2DMF。甲酰腙化合物和锌配合物的特征是通过 CHN 元素分析和红外光谱分析得出的。单晶 X 射线测定进一步证实了其详细结构。配合物中的锌原子与一个 L 配体的苯酚 O 原子、亚氨基 N 原子和羰基 O 原子以及另一个 L 配体的苯酚 O 原子呈方形金字塔配位，一个 I 配体位于顶端位置。甲酰腙和锌配合物的晶体结构由氢键稳定。对这两种化合物进行了蚕豆脲酶活性测试。结果表明，锌复合物具有有效的活性，其 IC50 值为 1.7 ± 0.3 μmol/L。
Synthesis, Crystal Structures and Urease Inhibition of N’-(2-Hydroxy-4-Methoxybenzylidene)-4-Nitrobenzohydrazide and its Zinc(II) Complex
An aroylhydrazone compound N’-(2-hydroxy-4-methoxybenzylidene)-4-nitrobenzohydrazide (HL) was prepared. Reaction of the aroylhydrazone compound with zinc iodide afforded a dinuclear zinc(II) complex [Zn2I2L2]∙2DMF. The aroylhydrazone compound and the zinc complex were characterized by CHN elemental analyses and infrared spectroscopy. Detailed structures are further confirmed by single crystal X-ray determination. The Zn atom in the complex is in square pyramidal coordination, with the phenolate O, imino N and carbonyl O atoms of one L ligand, and the phenolate O atom of the other L ligand in the basal plane, and with one I ligand at the apical position. The crystal structures of the aroylhydrazone and the zinc complex are stabilized by hydrogen bonds. The two compounds have been tested for their Jack bean urease activity. As a result, the zinc complex has effective activity with IC50 value of 1.7 ± 0.3 μmol/L.
期刊介绍：
Journal is an interdisciplinary publication covering all aspects of structural chemistry, including the theory of molecular structure and chemical bond; the use of physical methods to study the electronic and spatial structure of chemical species; structural features of liquids, solutions, surfaces, supramolecular systems, nano- and solid materials; and the crystal structure of solids.
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