铜催化 2-卤化苯甲酸和炔烃合成 3-取代的异香豆素

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Sciences Pub Date : 2024-11-11 DOI:10.1007/s12039-024-02311-4

Xiao-Li Qin, Xue-Qing Ding, Yu-Qin Li, Yi-Hao Yu, Fan Xu, Zhou Rong

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引用次数: 0

摘要

一种在铜催化下合成3-取代的异香豆素的方法，包括邻溴苯甲酸和炔烃在二甲基亚砜中的环化反应，在K2CO3的帮助下于100 °C进行。图解摘要一种在铜催化下合成 3-取代异香豆素的方法涉及邻溴苯甲酸和炔烃在二甲基亚砜中的环化反应，该反应在 K2CO3 的辅助下于 100 ℃ 进行。该反应显示，3-取代的异香豆素的合成收率为 8-81%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Copper-catalyzed synthesis of 3-substituted isocoumarins from 2-halogenation benzoic acid and alkynes

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Copper-catalyzed synthesis of 3-substituted isocoumarins from 2-halogenation benzoic acid and alkynes

A method for synthesizing 3-substituted isocoumarins under copper catalysis involves the cyclization reaction of o-bromobenzoic acid and alkynes in DMSO, with the assistance of K₂CO₃ at 100 °C. It exhibits a wide range of substrate compatibility and excellent tolerance towards diverse functional groups.

Graphical abstract

A method for synthesizing 3-substituted isocoumarins under copper catalysis involves the cyclization reaction of o-bromobenzoic acid and alkynes in DMSO, with the assistance of K₂CO₃ at 100 °C. This reaction demonstrates a synthesis yield of 8–81% for 3-substituted isocoumarins.

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.