骨髓中的内皮异质性:对发育、成年和白血病的认识

IF 12.8 1区 医学 Q1 HEMATOLOGY
I. L. Boueya, L. Sandhow, J. R. P. Albuquerque, R. Znaidi, D. Passaro
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引用次数: 0

摘要

内皮微环境在协调骨髓(BM)稳态和造血支持方面的核心作用已在不同发育阶段和成年期得到证实。骨髓血管在介导骨髓实质和循环血液之间的交流方面至关重要,在结构和功能方面表现出显著的异质性。虽然人们早已认识到其他组织中血管细胞的多样性,但这种现象在 BM 中的分子基础现在才刚刚出现。在过去十年中,单细胞方法和显微观察拓展了我们对 BM 血管的认识。过去,内皮细胞只具有旁分泌特性,而最近的研究进展彻底改变了我们对内皮细胞功能的认识,揭示了与不同内皮细胞状态相关的不同解剖位置。因此,对正常和病理状态下表型差异的识别加深了我们对血管动态及其对健康和疾病中造血的影响的理解。在这篇综述中,我们将重点介绍在了解发育、成年和衰老过程中骨髓微环境中血管异质性方面的重要里程碑和最新进展。我们还探讨了白血病如何影响这种异质性,以及如何利用这些知识改进临床实践。通过综合现有文献,我们旨在解决尚未解决的问题,并概述未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Endothelial heterogeneity in bone marrow: insights across development, adult life and leukemia

Endothelial heterogeneity in bone marrow: insights across development, adult life and leukemia

The central role of the endothelial microenvironment in orchestrating bone marrow (BM) homeostasis and hematopoietic support has been confirmed at various developmental stages and in adult life. The BM vasculature is crucial in mediating communication between BM parenchyma and circulating blood, displaying remarkable heterogeneity in structure and function. While vascular cell diversity in other tissues has long been recognized, the molecular basis of this phenomenon in BM is just now emerging. Over the past decade, single-cell approaches and microscopic observations have expanded our understanding of BM vasculature. While solely characterized for their paracrine properties in the past, recent advances have revolutionized our perception of endothelial function, revealing distinct anatomical locations associated with diverse endothelial cell states. The identification of phenotypic differences between normal and pathological conditions has therefore deepened our understanding of vascular dynamics and their impact on hematopoiesis in health and disease. In this review, we highlight key milestones and recent advances in understanding vascular heterogeneity within BM microenvironment during development, adulthood and aging. We also explore how leukemia affects this heterogeneity and how we can take this knowledge forward to improve clinical practices. By synthesizing existing literature, we aim to address unresolved questions and outline future research directions.

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来源期刊
Leukemia
Leukemia 医学-血液学
CiteScore
18.10
自引率
3.50%
发文量
270
审稿时长
3-6 weeks
期刊介绍: Title: Leukemia Journal Overview: Publishes high-quality, peer-reviewed research Covers all aspects of research and treatment of leukemia and allied diseases Includes studies of normal hemopoiesis due to comparative relevance Topics of Interest: Oncogenes Growth factors Stem cells Leukemia genomics Cell cycle Signal transduction Molecular targets for therapy And more Content Types: Original research articles Reviews Letters Correspondence Comments elaborating on significant advances and covering topical issues
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