EgtB-IV 结构中留下的趋同进化痕迹

IF 4.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Structure Pub Date : 2024-11-07 DOI:10.1016/j.str.2024.10.006

Taku Mizutani, Ikuro Abe

引用次数: 0

摘要

在酶的区域选择性催化下，半胱氨酸亚砜掺入组氨酸中，产生了麦角硫因和卵硫醇等重要的生理抗氧化剂。在本期的《结构》杂志上，Ireland 等人1 报告了 EgtB-IV 的晶体结构，该结构提供了有关亚砜合成酶趋同进化的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Traces of convergent evolution left in the structure of EgtB-IV

The enzymatically regioselective catalyzed incorporation of cysteine sulfoxide into histidine generates physiologically important antioxidants such as ergothioneine and ovothiol. In this issue of Structure, Ireland et al.¹ report the crystal structure of EgtB-IV, which provides insights into the convergent evolution of sulfoxide synthase.

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来源期刊

Structure 生物-生化与分子生物学

CiteScore

8.90

自引率

1.80%

发文量

155

审稿时长

3-8 weeks

期刊介绍： Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding, and/or design, will also be considered. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single-molecule analysis of biological mechanisms are welcome. In general, the editors encourage submission of experimental structural studies that are enriched by an analysis of structure-activity relationships and will not consider studies that solely report structural information unless the structure or analysis is of exceptional and broad interest. Studies reporting only homology models, de novo models, or molecular dynamics simulations are also discouraged unless the models are informed by or validated by novel experimental data; rationalization of a large body of existing experimental evidence and making testable predictions based on a model or simulation is often not considered sufficient.