帽子特异性 m6Am 修饰：通过封存 PCF11 成为转录反终止子，对神经母细胞瘤治疗具有重要意义

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-11-07 DOI:10.1016/j.molcel.2024.10.014

Shinichiro Akichika, Tsutomu Suzuki

引用次数: 0

摘要

在本期的《分子细胞》（Molecular Cell）杂志上，An 等人1 报道了帽特异性 m6Am 修饰的一种新功能，即通过封存转录终止子 PCF11 来作为 RNA 聚合酶 II 过早转录的抗终止子。这项研究为转录控制和癌症治疗中的 RNA 修饰提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cap-specific m6Am modification: A transcriptional anti-terminator by sequestering PCF11 with implications for neuroblastoma therapy

In this issue of Molecular Cell, An et al.¹ reports a novel function of cap-specific m⁶Am modification acting as an anti-terminator for premature RNA polymerase II transcription by sequestering a transcriptional terminator PCF11. This study provides new insights into RNA modifications in transcriptional control and cancer treatment.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.