细胞群分数杀伤过程中的生存共振

IF 8.1 1区物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY

Physical review letters Pub Date : 2024-11-07 DOI:10.1103/physrevlett.133.198401

Francesco Puccioni, Johannes Pausch, Paul Piho, Philipp Thomas

{"title":"细胞群分数杀伤过程中的生存共振","authors":"Francesco Puccioni, Johannes Pausch, Paul Piho, Philipp Thomas","doi":"10.1103/physrevlett.133.198401","DOIUrl":null,"url":null,"abstract":"Fractional killing in response to drugs is a hallmark of nongenetic cellular heterogeneity. Yet how individual lineages evade drug treatment, as observed in bacteria and cancer cells, is not quantitatively understood. We study a stochastic population model with age-dependent division and death rates, allowing for persistence. In periodic drug environments, we discover peaks in the survival probabilities at division or death times that are multiples of the environment duration. The survival resonances are unseen in unstructured populations and are amplified by persistence.","PeriodicalId":20069,"journal":{"name":"Physical review letters","volume":"127 1","pages":""},"PeriodicalIF":8.1000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Survival Resonances during Fractional Killing of Cell Populations\",\"authors\":\"Francesco Puccioni, Johannes Pausch, Paul Piho, Philipp Thomas\",\"doi\":\"10.1103/physrevlett.133.198401\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Fractional killing in response to drugs is a hallmark of nongenetic cellular heterogeneity. Yet how individual lineages evade drug treatment, as observed in bacteria and cancer cells, is not quantitatively understood. We study a stochastic population model with age-dependent division and death rates, allowing for persistence. In periodic drug environments, we discover peaks in the survival probabilities at division or death times that are multiples of the environment duration. The survival resonances are unseen in unstructured populations and are amplified by persistence.\",\"PeriodicalId\":20069,\"journal\":{\"name\":\"Physical review letters\",\"volume\":\"127 1\",\"pages\":\"\"},\"PeriodicalIF\":8.1000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physical review letters\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1103/physrevlett.133.198401\",\"RegionNum\":1,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physical review letters","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1103/physrevlett.133.198401","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

对药物的分化杀伤是非遗传细胞异质性的标志。然而，人们对细菌和癌细胞中观察到的单个细胞系如何逃避药物治疗还没有定量的了解。我们研究了一个随机种群模型，该模型的分裂率和死亡率与年龄有关，并允许持续存在。在周期性药物环境中，我们发现在分裂或死亡时间的生存概率峰值是环境持续时间的倍数。这种存活共振在非结构化种群中是看不到的，并通过持久性得到了放大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Survival Resonances during Fractional Killing of Cell Populations

Fractional killing in response to drugs is a hallmark of nongenetic cellular heterogeneity. Yet how individual lineages evade drug treatment, as observed in bacteria and cancer cells, is not quantitatively understood. We study a stochastic population model with age-dependent division and death rates, allowing for persistence. In periodic drug environments, we discover peaks in the survival probabilities at division or death times that are multiples of the environment duration. The survival resonances are unseen in unstructured populations and are amplified by persistence.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Physical review letters 物理-物理：综合

CiteScore

16.50

自引率

7.00%

发文量

2673

审稿时长

2.2 months

期刊介绍： Physical review letters(PRL)covers the full range of applied, fundamental, and interdisciplinary physics research topics: General physics, including statistical and quantum mechanics and quantum information Gravitation, astrophysics, and cosmology Elementary particles and fields Nuclear physics Atomic, molecular, and optical physics Nonlinear dynamics, fluid dynamics, and classical optics Plasma and beam physics Condensed matter and materials physics Polymers, soft matter, biological, climate and interdisciplinary physics, including networks