减少使用可卡因对免疫功能指标的影响

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2024-10-28 DOI:10.1016/j.jneuroim.2024.578470

William W. Stoops , Thomas P. Shellenberg , Sean D. Regnier , David H. Cox , Reuben Adatorwovor , Lon R. Hays , Danielle M. Anderson , Joshua A. Lile , Joy M. Schmitz , Jennifer R. Havens , Suzanne C. Segerstrom

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引用次数: 0

摘要

本研究确定了减少可卡因使用对免疫功能的影响。患有可卡因使用障碍的求治者参加了为期 12 周的应急管理试验，以减少可卡因的使用。参与者按 1:1:1 的比例被随机分配到高价值强化物（即 55 美元/阴性尿样）以戒除可卡因（n = 41）、低价值强化物（即 13 美元/阴性尿样）以戒除可卡因（n = 33）或非权变控制（n = 33）。每隔 6 周收集一次免疫测定结果。高价值组的用量减少最多，红斑和 IL-6 增加，IL-10 和 CCL5 减少，表明免疫反应被激活。减少使用可卡因可能会促进免疫健康的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Influence of cocaine use reduction on markers of immune function

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Influence of cocaine use reduction on markers of immune function

This study determined the effects of reduced cocaine use on immune function. Treatment seeking participants with Cocaine Use Disorder enrolled in a 12-week contingency management trial to reduce cocaine use. Participants were randomly assigned 1:1:1 to High Value Reinforcers (i.e., $55/negative urine sample) for cocaine abstinence (n = 41), Low Value Reinforcers (i.e., $13/negative urine sample) for cocaine abstinence (n = 33) or Non-Contingent Control (n = 33). Immune measures were collected at 6-week intervals. The High Value group had greatest use reductions, increased erythema and IL-6 and decreased IL-10 and CCL5, suggesting an activated immune response. Cocaine use reduction may promote changes in immune health.

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.