酒精对脑电图活动的影响:以青少年性别差异为重点的系统性综述。

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Adrián S Elliott, Román D Moreno-Fernández, Patricia Sampedro-Piquero
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引用次数: 0

摘要

背景:大多数关于酒精的脑电图(EEG)研究都集中在成年人身上,而关于脑电图测量在检测高危青少年以及了解酒精对大脑影响的性别差异方面的潜力,目前还缺乏相关数据:本系统综述旨在探讨酒精滥用、酒精使用障碍(AUD)青少年以及酒精使用障碍家庭后代的脑电图与性别相关的差异:方法:按照 PRISMA 指南对文献进行系统综述。综述方案已在 Prospero 注册(ID:CRD42024511471)。经过文章筛选和质量评估,25 项研究被纳入我们的综述。检索对象包括年龄在 12 至 30 岁之间、有 DSM、AUDIT 或特定酒精滥用问卷所定义的问题酒精消费的参与者:患有 AUD 的年轻男性的 beta 值通常较高,他们通常表现出更强的大脑半球间连通性(interHC),而患有 AUD 的年轻女性则倾向于增强大脑半球内连通性(intraHC)。P3 似乎对酒精滥用特别敏感,男性的振幅通常低于年轻女性。其他事件相关电位(ERPs),如N415、P640和错误相关负性(ERN)缺乏足够的方法学支持,无法得出性别差异的结论:结论:在临床研究中考虑性别变量将增强我们对大脑功能和结构变化的理解,从而为 AUD 制定量身定制的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth.

Background: Most electroencephalographic (EEG) investigations on alcohol have focused on adults, and scarce data is available about the potential of EEG measurements to detect young people at high-risk, as well as, to understand possible sex differences in alcohol impact on the brain.

Objective: This systematic review aimed to explore sex-related differences in EEG among young people with alcohol misuse, alcohol use disorder (AUD), and offspring of families with AUD.

Methods: A systematic review of the literature was conducted following PRISMA guidelines. Review protocol was registered in Prospero (ID: CRD42024511471). After article selection process and quality assessment, 25 studies were included in our review. The search included participants between 12 and 30 years old with problematic alcohol consumption, as defined by DSM, AUDIT, or specific alcohol misuse questionnaires.

Results: It seems that beta was generally higher in young males with AUD, and they usually exhibited greater interhemispheric connectivity (interHC), whereas young females with AUD tended towards enhanced intraHC. P3 appears to be particularly sensitive to alcohol misuse, with males typically exhibiting a lower amplitude than young females. Other event related potentials (ERPs) such as N415, P640, and the error-related negativity (ERN) lacked sufficient methodological support to draw conclusions regarding sex differences, N340 and P540 suggested avenues for expanding research on memory processing, indicating differences in amplitude between males and females.

Conclusion: Considering sex variables in clinical research will enhance our understanding of alterations in brain function and structure with the goal of tailoring treatment strategies for AUD.

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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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