病毒感染中的短链脂肪酸:潜在机制、机遇和挑战。

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yee Tsui, Xueqi Wu, Xi Zhang, Ye Peng, Chris Ka Pun Mok, Francis K L Chan, Siew C Ng, Hein Min Tun
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引用次数: 0

摘要

病毒感染可导致细胞通路失调、细胞死亡和免疫病理反应,从而引发宿主炎症。微生物群产生的短链脂肪酸(SCFAs)能够调节这些过程,因此已成为治疗病毒感染的潜在疗法。然而,据报道 SCFAs 既有有益的作用,也有有害的作用,因此有必要全面了解其潜在机制。本综述强调了 SCFAs 对病毒感染结果产生影响的复杂机制。我们还强调了考虑 SCFAs 的活性在不同环境下如何产生差异的重要性,这些环境包括但不限于具有不同代谢线路的靶细胞、不同的病毒感染原因、靶生物体/细胞的营养供应和/或能量平衡以及具有不同微生物组组成的宿主。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Short-chain fatty acids in viral infection: the underlying mechanisms, opportunities, and challenges.

Viral infections can cause cellular pathway derangements, cell death, and immunopathological responses, leading to host inflammation. Short-chain fatty acids (SCFAs), produced by the microbiota, have emerged as a potential therapeutic for viral infections due to their ability to modulate these processes. However, SCFAs have been reported to have both beneficial and detrimental effects, necessitating a comprehensive understanding of the underlying mechanisms. This review highlights the complex mechanisms underlying SCFAs' effects on viral infection outcomes. We also emphasize the importance of considering how SCFAs' activities may differ under diverse contexts, including but not limited to target cells with different metabolic wiring, different viral causes of infection, the target organism/cell's nutrient availability and/or energy balance, and hosts with varying microbiome compositions.

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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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