在全基因组研究中使用条件对称多维高斯混合物检验大量复合零假设

IF 3 1区数学 Q1 STATISTICS & PROBABILITY

Journal of the American Statistical Association Pub Date : 2024-11-04 DOI:10.1080/01621459.2024.2422124

Ryan Sun, Zachary R. McCaw, Xihong Lin

引用次数: 0

摘要

因果中介分析、多效性分析和复制分析是三种非常流行的遗传研究设计。虽然这些分析解决的科学问题不同，但其基本的统计信息却相同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Testing a Large Number of Composite Null Hypotheses Using Conditionally Symmetric Multidimensional Gaussian Mixtures in Genome-Wide Studies

Causal mediation, pleiotropy, and replication analyses are three highly popular genetic study designs. Although these analyses address different scientific questions, the underlying statistical inf...

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来源期刊

Journal of the American Statistical Association 数学-统计学与概率论

CiteScore

7.50

自引率

8.10%

发文量

168

审稿时长

12 months

期刊介绍： Established in 1888 and published quarterly in March, June, September, and December, the Journal of the American Statistical Association ( JASA ) has long been considered the premier journal of statistical science. Articles focus on statistical applications, theory, and methods in economic, social, physical, engineering, and health sciences. Important books contributing to statistical advancement are reviewed in JASA . JASA is indexed in Current Index to Statistics and MathSci Online and reviewed in Mathematical Reviews. JASA is abstracted by Access Company and is indexed and abstracted in the SRM Database of Social Research Methodology.