甘油三酯-葡萄糖指数及其与肥胖指标的结合介导了 2-羟基芴与心血管疾病患病率之间的关联:来自 NHANES(2005-2018 年)的证据

IF 6.2 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
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引用次数: 0

摘要

背景人们日益认识到,多环芳烃(PAHs)是一组与各种健康问题相关的环境污染物。环境中多环芳烃含量的增加令人担忧。本研究调查了暴露于 2-hydroxyfluorene 对心血管疾病患病率的影响,特别关注甘油三酯-葡萄糖(TyG)指数的中介作用及其与肥胖指标的结合。方法利用 2005 年至 2018 年的美国国家健康与营养调查(NHANES)数据,通过各种统计技术评估 2-hydroxyfluorene 如何影响心血管疾病患病率。调查首先采用受限立方样条线(RCS)分析,探讨2-羟基芴水平与心血管疾病患病率之间的关系。然后使用逻辑回归和贝叶斯核机器回归模型(BKMR)来检验多环芳烃混合物中的相关性。此外,还使用了量子G计算(QG-comp)模型来评估权重和方向的影响。还进行了中介分析,以评估TyG相关指标对2-羟基芴与心血管疾病患病率之间关系的中介作用。此外,还评估了2-羟基芴与充血性心力衰竭、心肌梗死、心绞痛和冠心病等具体心血管疾病患病率之间的关系,并评估了中介效应。结果这项涉及 3645 名参与者的研究发现,2-羟基芴暴露与心血管疾病之间存在显著的正相关关系(OR (95 %CI) = 115.8013 (5.0521 ∼ 2654.3248),P=0.0029),其中 2-羟基芴对邻苯二甲酸酯混合物中心血管疾病的发病率有积极影响。2-羟基芴与每种特定心血管疾病的患病率之间也存在正相关。TyG和TyGWC(甘油三酯血糖-腰围)被认为是2-羟基芴暴露与总心血管疾病和每种特定心血管疾病发病率之间联系的介导因素,而TyGBMI(甘油三酯血糖-体重指数)只能介导2-羟基芴与总心血管疾病发病率之间的联系、结论:研究结果表明,2-羟基芴暴露与心血管疾病发病率之间存在显著关联,TyG 相关指标起中介作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Triglyceride-glucose Index and Its combination with obesity indicators mediating the association between 2-hydroxyfluorene and the prevalence of cardiovascular disease: Evidence from the NHANES (2005–2018)

Background

Polycyclic aromatic hydrocarbons (PAHs) were increasingly recognized as a group of environmental pollutants associated with various health issues. The rise in their prevalence in the environment was concerning. Yet, the effects of PAH exposure on cardiovascular diseases (CVDs) were still not well understood.

Purpose

This study investigated the impact of exposure to 2-hydroxyfluorene on CVDs prevalence, with a special focus on the mediating role of triglyceride-glucose (TyG) index and its combination with obesity indicators.

Method

Using National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2018, this study assessed how 2-hydroxyfluorene affects CVDs prevalence through various statistical techniques. The investigation began with restricted cubic spline (RCS) analysis to explore the relationship between 2-hydroxyfluorene levels and CVDs prevalence. Logistic regression was then used to examine associations within PAH mixtures, alongside the Bayesian Kernel Machine Regression (BKMR) model. Furthermore, the Quantile G-Computation (QG-comp) model was used to evaluate the influence of weights and directions. A mediation analysis was also performed to assess the mediating role of TyG-related indicators on the relationship between 2-hydroxyfluorene and CVDs prevalence. Besides, the association between 2-hydroxyfluorene and the prevalence of each specific CVDs, congestive heart failure, myocardium infarction, angina pectoris and coronary heart disease, was also assessed and so was the mediated effect. Finally, the subgroup analysis was conducted to assess the association in each specific subgroup.

Result

The study, involving 3645 participants, found a significant positive association between 2-hydroxyfluorene exposure and CVD (OR (95 %CI) = 115.8013 (5.0521 ∼ 2654.3248), P=0.0029), with 2-hydroxyfluorene showing the positive contribution to CVDs prevalence within the phthalate mixture. The positive association also existed between 2-hydroxyfluorene and the prevalence of each specific CVDs. TyG and TyGWC (Triglyceride Glucose-Waist Circumference) were identified as mediators in the link between 2-hydroxyfluorene exposure and the prevalence of total CVD and each specific CVD, while TyGBMI (Triglyceride Glucose-Body Mass Index) can only mediate the association between 2-hydroxyfluorene and the prevalence of total CVD, congestive heart failure and angina pectoris

Conclusion

The findings highlighted a significant association between 2-hydroxyfluorene exposure and CVDs prevalence, with TyG-related indicators acting as mediators.
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来源期刊
CiteScore
12.10
自引率
5.90%
发文量
1234
审稿时长
88 days
期刊介绍: Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.
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