Electroanalysis of Statin Drugs: A Review on the Electrochemical Sensor Architectures Ranging from Classical to Modern Systems.

An overview of the latest advances in the design of electrochemical sensor architectures dedicated to the determination of drugs from the statin class is presented in this review. Statins are drugs widely consumed for cholesterol control, and their determination in different matrices through the application of electroanalysis is growing considering advantages such as operational simplicity, lower cost and ease of sample preparation. Within the context of statins, electrochemical sensor architectures can be subdivided into conventional/classical electrodes such as glassy carbon electrodes, carbon paste electrodes, pencil graphite electrodes, boron-doped diamond electrodes and metallic electrodes, and more modern electrode systems, including the screen-printed electrodes and 3D-printed electrodes. Thus, different aspects related to the preparation of these electrochemical sensors and analytical performance are presented, also reflecting advances in terms of designs of new architectures and possible improvements not previously reviewed. Analyzed samples, advantages and disadvantages of different implemented sensor's modification strategies and perspectives for the electroanalysis of statins are also included throughout the work.