重新规划葡萄糖代谢，重新审视肝癌对经导管肝动脉化疗栓塞的耐受性。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2024-11-05 DOI:10.1002/cbic.202400719

Ruijie Zhang, Fan Dai, Songhan Deng, Yun Zeng, Jinyang Wang, Gang Liu

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引用次数: 0

摘要

肝细胞癌（HCC）是全球公认的致死率最高的肿瘤之一，因其极强的侵袭性和复发倾向而对患者的生命构成严重威胁。经导管肝动脉化疗栓塞（TACE）疗法作为晚期肝癌患者的一线治疗方案，已被证明是有效的。然而，令人沮丧的是，近 40% 的患者对该疗法表现出耐药性。因此，本综述深入研究了葡萄糖代谢的各个方面，以探索 TACE 治疗耐药背后的潜在机制，并提出可能富有成效的治疗策略。最终目的是为开发针对 HCC 的个性化治疗方法提供新的见解。

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Reprogramming of Glucose Metabolism for Revisiting Hepatocellular Carcinoma Resistance to Transcatheter Hepatic Arterial Chemoembolization.

Hepatocellular carcinoma (HCC) is recognized globally as one of the most lethal tumors, presenting a significant menace to patients' lives owing to its exceptional aggressiveness and tendency to recur. Transcatheter hepatic arterial chemoembolization (TACE) therapy, as a first-line treatment option for patients with advanced HCC, has been proven effective. However, it is disheartening that nearly 40 % of patients exhibit resistance to this therapy. Consequently, this review delves into the metabolic aspects of glucose metabolism to explore the underlying mechanisms behind TACE treatment resistance and to propose potentially fruitful therapeutic strategies. The ultimate objective is to present novel insights for the development of personalized treatment methods targeting HCC.

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).