作为前瞻性抗菌剂的异相 CuO/Cu2O/Ag 纳米粒子的一锅电爆炸合成法

IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR
Olga Bakina, Ludmila Ivanova, Andrey Miller, Anfisa Rechkunova
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引用次数: 0

摘要

由于新的抗生素耐药菌株的出现和扩散,以及对此类材料的有效性和毒性要求的不断提高,获得具有抗菌活性的新材料已成为一项紧迫任务。用双绞线电爆炸(EETW)来生产异相纳米粒子对开发新型抗菌剂很有吸引力。我们的工作描述了一种简单而环保的方法,即通过在含氧气氛中同时电爆银和铜双绞线,获得不同银质量比(15%、50%、90%)的新型 CuO/Cu2O/Ag 复合纳米粒子。使用 EETW 生产异相纳米粒子有几个优点,如纳米粒子纯度高、生产率高(每小时约 120 克纳米粒子)和环保。获得的纳米粒子具有不规则的球形形态。平均粒径取决于银含量,分别为 63 ± 2 nm(90%银)、92 ± 2 nm(15%银)。CuO/Cu2O/(50)Ag 的粒度分布有两个峰值,一个在 35 ± 1 nm,另一个在 79 ± 2 nm。在中性 pH 值和 25 °C 下测得的纳米粒子的 NP zeta 电位为正值(超过 20 mV)。含 50% Ag 的 CuO/Cu2O/Ag 纳米粒子能显著抑制耐甲氧西林金黄色葡萄球菌(MRSA)的生长,MIC = 62 µg/mL。采用盘扩散法测定的含 90%Ag 的纳米粒子的抗菌活性略低于含 15% 和 50%Ag 的纳米粒子。可能的抗菌机制可归因于 EETW 纳米粒子的异质结构的协同效应和电镀纳米对的形成。纳米粒子中银金属和铜氧化物的存在可促进电化学腐蚀,导致更多的金属离子释放到细菌悬浮液中。我们已经证明,与银纳米粒子不同,所获得的纳米粒子具有正的 zeta 电位,这可能有助于纳米粒子更好地附着在细菌细胞表面。合成的纳米粒子作为一种有效的抗菌纳米材料,具有广泛的医药开发潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

One-Pot Electrical Explosion Synthesis of Heterophase CuO/Cu2O/Ag Nanoparticles as a Perspective Antimicrobial Agent

One-Pot Electrical Explosion Synthesis of Heterophase CuO/Cu2O/Ag Nanoparticles as a Perspective Antimicrobial Agent

Obtaining new materials with antibacterial activity is an urgent task due to the emergence and proliferation of new antibiotic resistant strains, as well as the increasing requirements for the effectiveness and toxicity of such materials. Electrical explosion of two twisted wires (EETW) to produce of heterophase nanoparticles is attractive for develop novel antibacterial agents. Our work describes simple and environmental friendly way to obtain novel composite CuO/Cu2O/Ag nanoparticles with different silver mass ratio (15, 50, 90%) by the simultaneous electrical explosion of Ag and Cu twisted wires in oxygen containing atmosphere. The using of EETW for the production of heterophase NPs is due to several advantages such as high purity of nanoparticles, good productivity (about 120 g nanoparticles per hour) and eco-friendliness. The obtained nanoparticles have irregular spherical shape morphology. According to EDX analysis dates, the nanoparticles have Janus-like structure, where one part is enriched with Ag and the other with Cu and O. The mean particle size depended on silver content and was 63 ± 2 nm (90% Ag), 92 ± 2 nm (15% Ag). CuO/Cu2O/(50)Ag particle size distribution have two peaks, one at 35 ± 1 nm and the other at 79 ± 2 nm. The NP zeta potential of nanoparticles measured neutral pH and 25 °C was positive (more than 20 mV). CuO/Cu2O/Ag nanoparticles with 50% Ag significantly inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA) with MIC = 62 µg/mL. The antibacterial activity nanoparticles with 90%Ag determined by the disco-diffusion method was slightly lower than that of the nanoparticles with 15 and 50% Ag. The possible antibacterial mechanisms may be attributed to the synergistic effect of the heterostructure of EETW nanoparticles and the formation of galvanic nanopairs. The presence of silver metal and copper oxides in nanoparticles can promote galvanic corrosion, leading to the release of more metal ions into the bacterial suspension. We have shown that the nanoparticles obtained have a positive zeta potential, unlike Ag nanoparticles, which may contribute to a better adhesion of nanoparticles to the surface of bacterial cells. The synthesized NPs have broad potential to be developed in pharmaceutics as an effective antimicrobial nanomaterial.

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来源期刊
Journal of Cluster Science
Journal of Cluster Science 化学-无机化学与核化学
CiteScore
6.70
自引率
0.00%
发文量
166
审稿时长
3 months
期刊介绍: The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.
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