孟加拉国五岁以下儿童在接种 10 价肺炎球菌结合疫苗前患社区获得性肺炎的肺炎链球菌血清型分布。

IF 8.5 Q1 RESPIRATORY SYSTEM
Stefan M T Vestjens, Suzan P van Mens, Bob Meek, Tariq A Lalmahomed, Ben de Jong, Doli Goswami, Bart J M Vlaminckx, Dilruba Ahmed, Bartelt M de Jongh, Hubert P Endtz, W Abdullah Brooks, Ger T Rijkers
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引用次数: 0

摘要

背景:肺炎链球菌是全球儿童细菌性肺炎最常见的致病病原体。孟加拉国于 2015 年将 10 价肺炎球菌结合疫苗 (PCV10) 引入其婴儿国家免疫计划。我们对 PCV10 引入前几年五岁以下儿童社区获得性肺炎(CAP)的潜在接种率进行了评估:方法:共采集了 1502 例儿童肺炎病例(结果显示:1 例病例的肺炎球菌血清学检测结果为阳性,1 例病例的肺炎球菌检测结果为阴性):经血清学鉴定,406/1380(29%)例肺炎球菌为致病病原体。最常见的五种血清型依次为 11A、22F、3、2 和 19F。根据与 PCV10 疫苗类型相关的肺炎病例百分比,PCV10 疫苗的潜在覆盖率为 29% (116/406):结论:在近三分之一的研究病例中,肺炎双球菌被确定为致病病原体。由于免疫测定的特点,这一结果很可能被严重低估。不过,PCV10 的潜在覆盖率很低。鉴于血清型的高度多样性,该地区可能会从覆盖率更高的 PCV 或重组蛋白疫苗中受益匪浅。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Streptococcus pneumoniae serotype distribution in Bangladeshi under-fives with community-acquired pneumonia pre-10-valent pneumococcal conjugate vaccination.

Background: Streptococcus pneumoniae is the most frequent causative pathogen of bacterial pneumonia in children worldwide. Bangladesh introduced the 10-valent pneumococcal conjugate vaccine (PCV10) in their national immunization program for infants in 2015. We assessed its potential coverage in under-fives with community-acquired pneumonia (CAP) in the years before PCV10 was introduced.

Methods: A total of 1502 childhood pneumonia cases (< 5 year olds living in the urban section Kamalapur, Dhaka) were enrolled between 2011 and 2013. Acute phase and late (convalescent) serum samples were collected from 1380 cases. Serotype-specific pneumococcal antibody concentrations were measured using a 25-plex immunoassay panel. Pneumococcal CAP was diagnosed based on a serotype-specific pneumococcal antibody response.

Results: S. pneumoniae was serologically identified as causative pathogen in 406/1380 (29%) cases. The five most prevalent serotypes were (in descending order) 11A, 22F, 3, 2 and 19F. Based on the percentage of pneumonia cases associated with PCV10 vaccine types, the potential PCV10 coverage was 29% (116/406).

Conclusions: In almost a third of the studied cases S. pneumoniae was identified as a causative pathogen. Because of the characteristics of the immunoassay, this might well be a gross underestimation. Nevertheless, the potential PCV10-coverage was low. Given the high serotype diversity, the region might benefit greatly from a higher-coverage PCV or recombinant protein vaccine.

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Pneumonia
Pneumonia RESPIRATORY SYSTEM-
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1.50%
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审稿时长
11 weeks
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