多酚在利用体外和体内模型逆转阿尔茨海默病病理机制方面的治疗潜力:全面综述。

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Monalisha Samal, Varsha Srivastava, Muzayyana Khan, Areeba Insaf, Naveen Reddy Penumallu, Aftab Alam, Bushra Parveen, Shahid Hussain Ansari, Sayeed Ahmad
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引用次数: 0

摘要

阿尔茨海默病(AD)被认为是与记忆和认知障碍有关的最常见的神经系统疾病之一,主要影响 65 岁或以上的人群。即使现代神经科学取得了巨大进步,但这种致残性疾病的永久性补救措施或治愈方法仍然遥不可及。多酚是一组天然存在的强效化合物,可以调节注意力缺失症典型的神经退行性过程。本综合研究旨在了解多酚的临床前和临床潜力,并阐明其在控制注意力缺失症方面的可能机制。此外,我们还回顾了将多酚类化合物作为单一化合物或联合疗法进行研究的不同临床研究,包括目前正在招募、已完成、已终止、已撤出或已暂停的 AD 治疗研究。根据体外细胞系研究和证明其神经保护潜力的临床前数据,通过谷歌学术、PubMed 和 Scopus 等电子数据库对天然多酚进行了系统筛选和鉴定。共鉴定出 63 种重要的多酚。研究提出了多酚作用模式的多机制途径。在 63 种多酚中,根据其临床疗效报告,有四种强效多酚被确定为有希望的潜在候选物质。多酚类物质作为一种植物药,可作为一种辅助治疗手段,为未来药物分子的开发提供了巨大的空间。不过,还需要利用新型给药方法和组合方法进行更多高质量的研究,以克服生物利用度和血脑屏障穿越等障碍,从而强调这些化合物在治疗注意力缺失症方面的治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic Potential of Polyphenols in Cellular Reversal of Patho-Mechanisms of Alzheimer's Disease Using In Vitro and In Vivo Models: A Comprehensive Review.

Alzheimer's disease (AD) is considered one of the most common neurological conditions associated with memory and cognitive impairment and mainly affects people aged 65 or above. Even with tremendous progress in modern neuroscience, a permanent remedy or cure for this crippling disease is still unattainable. Polyphenols are a group of naturally occurring potent compounds that can modulate the neurodegenerative processes typical of AD. The present comprehensive study has been conducted to find out the preclinical and clinical potential of polyphenols and elucidate their possible mechanisms in managing AD. Additionally, we have reviewed different clinical studies investigating polyphenols as single compounds or cotherapies, including those currently recruiting, completed, terminated, withdrawn, or suspended in AD treatment. Natural polyphenols were systematically screened and identified through electronic databases including Google Scholar, PubMed, and Scopus based on in vitro cell line studies and preclinical data demonstrating their potential for neuroprotection. A total of 63 significant polyphenols were identified. A multimechanistic pathway for polyphenol's mode of action has been proposed in the study. Out of 63, four potent polyphenols have been identified as promising potential candidates, based on their reported clinical efficacy. Polyphenols hold tremendous scope for the development of a future drug molecule as a phytopharmaceutical that may be incorporated as an adjuvant to the therapeutic regime. However, more high-quality studies with novel delivery methods and combinatorial approaches are required to overcome obstacles such as bioavailability and blood-brain barrier crossing to underscore the therapeutic potential of these compounds in AD management.

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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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