首次在人体中利用微粘合亲和血液过滤器快速清除实体肿瘤转移中的循环肿瘤细胞。

IF 2.2 3区医学 Q3 HEMATOLOGY

Blood Purification Pub Date : 2024-11-04 DOI:10.1159/000542325

Sanja Ilic, Vedran Premuzic

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引用次数: 0

摘要

简介我们首次进行了一项人体试验，评估在实体肿瘤转移患者中联合清除病原体和CTC的安全性和潜力：在一家血液透析诊所连续对 10 名转移性癌症患者实施了 Seraph 程序，这些患者的液体活检结果显示上皮细胞粘附分子 (EpCAM) 呈阳性。所有患者的细菌或真菌分离物均呈阳性：结果：我们证明了 Seraph100® 过滤器清除病原体和循环肿瘤细胞的能力，在 120 分钟内，患者血液中的病原体和循环肿瘤细胞中位数减少了 71%：讨论：高产量的 CTCs 清除率有可能使患者在癌症诊断和个性化治疗中受益，这一点有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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First In Human Rapid Removal of Circulating Tumor Cells in Solid Metastatic Neoplasia By Microbind Affinity Blood Filter.

Introduction: We conducted a first-in-human trial evaluating safety and the potential for combined pathogen and CTC removal in patients with solid metastatic cancers.

Methods: The Seraph procedure was performed at a hemodialysis clinic on ten consecutive patients with metastatic cancer whose liquid biopsy was positive for the epithelial cell adhesion molecule (EpCAM). All of the patients exerted positive bacterial or fungal isolates.

Results: We have demonstrated the ability of Seraph100® Filter to remove both pathogens and circulating tumor cells, with median reduction of 71% within the 120 min, from patient blood.

Discussion: High yield CTCs clearance could potentially benefit patients in diagnostic and personalized treatment of cancer to be elucidated in further research.

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来源期刊

Blood Purification 医学-泌尿学与肾脏学

CiteScore

5.80

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Practical information on hemodialysis, hemofiltration, peritoneal dialysis and apheresis is featured in this journal. Recognizing the critical importance of equipment and procedures, particular emphasis has been placed on reports, drawn from a wide range of fields, describing technical advances and improvements in methodology. Papers reflect the search for cost-effective solutions which increase not only patient survival but also patient comfort and disease improvement through prevention or correction of undesirable effects. Advances in vascular access and blood anticoagulation, problems associated with exposure of blood to foreign surfaces and acute-care nephrology, including continuous therapies, also receive attention. Nephrologists, internists, intensivists and hospital staff involved in dialysis, apheresis and immunoadsorption for acute and chronic solid organ failure will find this journal useful and informative. ''Blood Purification'' also serves as a platform for multidisciplinary experiences involving nephrologists, cardiologists and critical care physicians in order to expand the level of interaction between different disciplines and specialities.