昼夜节律对弱视治疗效果的潜在影响

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2024-11-01 DOI:10.1016/j.mehy.2024.111514

Saeed Aljohani

{"title":"昼夜节律对弱视治疗效果的潜在影响","authors":"Saeed Aljohani","doi":"10.1016/j.mehy.2024.111514","DOIUrl":null,"url":null,"abstract":"<div><div>Traditional treatments for amblyopia, such as patching and atropine penalization, often yield variable outcomes, underscoring the need for alternative or supplementary strategies. Circadian rhythms, which regulate various physiological processes including those associated with ocular health, may significantly influence the success of these treatments. The report proposes three hypotheses: (1) aligning amblyopia treatments with circadian rhythms through the modulation of melatonin and dopamine levels may enhance treatment responsiveness, (2) synchronizing treatment schedules with the patient’s diurnal rhythms could improve effectiveness, and (3) disruptions in circadian rhythms might negatively affect treatment outcomes. The expected implications of these hypotheses suggest a need for further research into the interplay between circadian rhythms and amblyopia therapy to optimize outcomes.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111514"},"PeriodicalIF":2.1000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Potential circadian rhythms impacts on amblyopia treatment outcomes\",\"authors\":\"Saeed Aljohani\",\"doi\":\"10.1016/j.mehy.2024.111514\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Traditional treatments for amblyopia, such as patching and atropine penalization, often yield variable outcomes, underscoring the need for alternative or supplementary strategies. Circadian rhythms, which regulate various physiological processes including those associated with ocular health, may significantly influence the success of these treatments. The report proposes three hypotheses: (1) aligning amblyopia treatments with circadian rhythms through the modulation of melatonin and dopamine levels may enhance treatment responsiveness, (2) synchronizing treatment schedules with the patient’s diurnal rhythms could improve effectiveness, and (3) disruptions in circadian rhythms might negatively affect treatment outcomes. The expected implications of these hypotheses suggest a need for further research into the interplay between circadian rhythms and amblyopia therapy to optimize outcomes.</div></div>\",\"PeriodicalId\":18425,\"journal\":{\"name\":\"Medical hypotheses\",\"volume\":\"193 \",\"pages\":\"Article 111514\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical hypotheses\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306987724002573\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306987724002573","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

传统的弱视治疗方法，如贴眼膜和阿托品惩罚法，往往会产生不同的结果，这凸显了对替代或辅助策略的需求。昼夜节律调节着各种生理过程，包括与眼部健康相关的生理过程，可能会极大地影响这些治疗方法的成功与否。报告提出了三个假设：（1）通过调节褪黑激素和多巴胺水平，使弱视治疗与昼夜节律保持一致，可能会提高治疗的反应性；（2）使治疗计划与患者的昼夜节律同步，可以提高治疗效果；（3）昼夜节律的紊乱可能会对治疗效果产生负面影响。这些假设的预期影响表明，有必要进一步研究昼夜节律与弱视治疗之间的相互作用，以优化治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Potential circadian rhythms impacts on amblyopia treatment outcomes

Traditional treatments for amblyopia, such as patching and atropine penalization, often yield variable outcomes, underscoring the need for alternative or supplementary strategies. Circadian rhythms, which regulate various physiological processes including those associated with ocular health, may significantly influence the success of these treatments. The report proposes three hypotheses: (1) aligning amblyopia treatments with circadian rhythms through the modulation of melatonin and dopamine levels may enhance treatment responsiveness, (2) synchronizing treatment schedules with the patient’s diurnal rhythms could improve effectiveness, and (3) disruptions in circadian rhythms might negatively affect treatment outcomes. The expected implications of these hypotheses suggest a need for further research into the interplay between circadian rhythms and amblyopia therapy to optimize outcomes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.