Jie Liang, Yang Pan, Wenya Zhang, Darui Gao, Jingya Ma, Yanyu Zhang, Mengmeng Ji, Yiwen Dai, Yuling Liu, Yongqian Wang, Yidan Zhu, Bin Lu, Wuxiang Xie, Fanfan Zheng
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A total of 932 participants (63.7% women; mean age, 60.0±6.9 years) were included. Compared with the lowest tertile of carotid intima-media thickness, carotid plaques, and brachial-ankle pulse wave velocity, or a coronary artery calcification score=0, the highest tertile of carotid intima-media thickness (β=-0.065 SD/y [95% CI, -0.112 to -0.017]; <i>P</i>=0.008), carotid plaques (β=-0.070 SD/y [95% CI, -0.130 to -0.011]; <i>P</i>=0.021), and brachial-ankle pulse wave velocity (β=-0.057 SD/y [95% CI, -0.105 to -0.010]; <i>P</i>=0.018), and a coronary artery calcification score≥400 (β=-0.081 SD/y [95% CI, -0.153 to -0.008]; <i>P</i>=0.029) were significantly associated with a faster decline in semantic fluency after multivariable adjustment. Moreover, greater carotid intima-media thickness, coronary artery calcification, and brachial-ankle pulse wave velocity were significantly associated with a faster decline in global cognition.</p><p><strong>Conclusions: </strong>More significant atherosclerosis was associated with faster semantic fluency and global cognition declines.</p>","PeriodicalId":54370,"journal":{"name":"Journal of the American Heart Association","volume":" ","pages":"e036696"},"PeriodicalIF":5.0000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Associations Between Atherosclerosis and Subsequent Cognitive Decline: A Prospective Cohort Study.\",\"authors\":\"Jie Liang, Yang Pan, Wenya Zhang, Darui Gao, Jingya Ma, Yanyu Zhang, Mengmeng Ji, Yiwen Dai, Yuling Liu, Yongqian Wang, Yidan Zhu, Bin Lu, Wuxiang Xie, Fanfan Zheng\",\"doi\":\"10.1161/JAHA.124.036696\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study aimed to examine whether baseline atherosclerosis was associated with subsequent short-term domain-specific cognitive decline.</p><p><strong>Methods and results: </strong>This research was based on the BRAVE (Beijing Research on Aging and Vessel) study, a population-based prospective cohort study of adults aged 40 to 80 years, free of dementia. 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引用次数: 0
摘要
背景：这项研究旨在探讨基线动脉粥样硬化是否与随后的短期特定领域认知能力下降有关：本研究旨在探讨基线动脉粥样硬化是否与随后的短期特定领域认知能力下降有关：本研究基于BRAVE（北京老龄化与血管研究）研究，这是一项基于人群的前瞻性队列研究，研究对象为40至80岁、无痴呆症的成年人。在基线（2019年第1波）时，进行了认知评估和动脉粥样硬化测量，包括颈动脉内膜中层厚度、颈动脉斑块、冠状动脉钙化和肱踝脉搏波速度。在第 2 波（2022-2023 年）对认知功能进行了重新评估，采用线性混合模型进行分析。共纳入了 932 名参与者（63.7% 为女性；平均年龄为 60.0±6.9 岁）。与颈动脉内膜中层厚度、颈动脉斑块和肱踝脉搏波速度的最低三分层或冠状动脉钙化评分=0相比，颈动脉内膜中层厚度的最高三分层（β=-0.065 SD/y [95% CI, -0.112 to -0.017]；P=0.008）、颈动脉斑块（β=-0.070 SD/y [95% CI, -0.经多变量调整后，颈动脉斑块（β=-0.070 SD/y [95% CI, -0. 130 to -0.011]；P=0.021）、肱踝脉搏波速度（β=-0.057 SD/y [95% CI, -0.105 to -0.010]；P=0.018）和冠状动脉钙化评分≥400（β=-0.081 SD/y [95% CI, -0.153 to -0.008]；P=0.029）与语义流畅度下降速度显著相关。此外，颈动脉内中膜厚度、冠状动脉钙化和肱踝脉搏波速度越大，整体认知能力下降越快：结论：更严重的动脉粥样硬化与语义流畅性和整体认知能力下降更快有关。
Associations Between Atherosclerosis and Subsequent Cognitive Decline: A Prospective Cohort Study.
Background: This study aimed to examine whether baseline atherosclerosis was associated with subsequent short-term domain-specific cognitive decline.
Methods and results: This research was based on the BRAVE (Beijing Research on Aging and Vessel) study, a population-based prospective cohort study of adults aged 40 to 80 years, free of dementia. At baseline (wave 1, 2019), cognitive assessments and atherosclerosis measures, including carotid intima-media thickness, carotid plaques, coronary artery calcification, and brachial-ankle pulse wave velocity were conducted. Cognitive function was reassessed in wave 2 (2022-2023) using linear mixed models for analysis. A total of 932 participants (63.7% women; mean age, 60.0±6.9 years) were included. Compared with the lowest tertile of carotid intima-media thickness, carotid plaques, and brachial-ankle pulse wave velocity, or a coronary artery calcification score=0, the highest tertile of carotid intima-media thickness (β=-0.065 SD/y [95% CI, -0.112 to -0.017]; P=0.008), carotid plaques (β=-0.070 SD/y [95% CI, -0.130 to -0.011]; P=0.021), and brachial-ankle pulse wave velocity (β=-0.057 SD/y [95% CI, -0.105 to -0.010]; P=0.018), and a coronary artery calcification score≥400 (β=-0.081 SD/y [95% CI, -0.153 to -0.008]; P=0.029) were significantly associated with a faster decline in semantic fluency after multivariable adjustment. Moreover, greater carotid intima-media thickness, coronary artery calcification, and brachial-ankle pulse wave velocity were significantly associated with a faster decline in global cognition.
Conclusions: More significant atherosclerosis was associated with faster semantic fluency and global cognition declines.
期刊介绍：
As an Open Access journal, JAHA - Journal of the American Heart Association is rapidly and freely available, accelerating the translation of strong science into effective practice.
JAHA is an authoritative, peer-reviewed Open Access journal focusing on cardiovascular and cerebrovascular disease. JAHA provides a global forum for basic and clinical research and timely reviews on cardiovascular disease and stroke. As an Open Access journal, its content is free on publication to read, download, and share, accelerating the translation of strong science into effective practice.
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