单磷酸环鸟苷-单磷酸腺苷合成酶-干扰素基因刺激通路在糖尿病及其并发症中的作用。

IF 4.2 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Ming-Wei Fan, Jin-Lan Tian, Tan Chen, Can Zhang, Xin-Ru Liu, Zi-Jian Zhao, Shu-Hui Zhang, Yan Chen
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引用次数: 0

摘要

糖尿病(DM)是导致全球死亡的主要原因之一,而炎症是其发病和发展的重要因素。本综述总结了环磷酸鸟苷-单磷酸腺苷合成酶(cGAS)-干扰素基因刺激器(STING)通路介导炎症反应的具体机制。此外,报告还全面介绍了相关研究进展以及该通路在早期 DM、糖尿病胃肠病、糖尿病心肌病、非酒精性脂肪肝及其他并发症的发病机制中的参与。此外,研究还讨论了 cGAS-STING 在自主神经功能紊乱和肠道调节失调中的作用,这可能会导致消化系统并发症。总之,本研究全面分析了有关 cGAS-STING 通路靶向治疗药物的研究进展及其在 DM 精准治疗中的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications.

Diabetes mellitus (DM) is one of the major causes of mortality worldwide, with inflammation being an important factor in its onset and development. This review summarizes the specific mechanisms of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway in mediating inflammatory responses. Furthermore, it comprehensively presents related research progress and the subsequent involvement of this pathway in the pathogenesis of early-stage DM, diabetic gastroenteropathy, diabetic cardiomyopathy, non-alcoholic fatty liver disease, and other complications. Additionally, the role of cGAS-STING in autonomic dysfunction and intestinal dysregulation, which can lead to digestive complications, has been discussed. Altogether, this study provides a comprehensive analysis of the research advances regarding the cGAS-STING pathway-targeted therapeutic agents and the prospects for their application in the precision treatment of DM.

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来源期刊
World Journal of Diabetes
World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
自引率
2.40%
发文量
909
期刊介绍: The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
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