Cathlyn K Medina, Berk Aykut, Lauren E Parker, Neel K Prabhu, Lillian Kang, Ziv Beckerman, Jacob N Schroder, Douglas M Overbey, Joseph W Turek
{"title":"在小儿心脏移植手术中使用体内器官护理系统的早期单中心经验。","authors":"Cathlyn K Medina, Berk Aykut, Lauren E Parker, Neel K Prabhu, Lillian Kang, Ziv Beckerman, Jacob N Schroder, Douglas M Overbey, Joseph W Turek","doi":"10.1016/j.healun.2024.10.027","DOIUrl":null,"url":null,"abstract":"<p><p>Pediatric heart transplantation (HTx) faces challenges such as limited donor availability and the need for complex reconstructions, particularly in patients with congenital anomalies. Ex vivo perfusion offers a promising approach to minimize graft ischemic time and potentially expand the donor pool. We report our single-center experience using the TransMedics Organ Care System (OCS) for ex vivo perfusion in pediatric HTx. From 2020-2024, eight pediatric patients received OCS-perfused donor hearts. Median recipient age was 13 years (range 9-18), and median weight was 58.8 kg (33.2-127.8). Indications for HTx included dilated cardiomyopathy (n=4), hypertrophic cardiomyopathy (n=1), graft vasculopathy (n=1), and Fontan failure (n=2). Median OCS time was 273 minutes (195-328), and recipient ischemic time was 85 minutes (64-139). Post-transplant, all patients had normal LV function at discharge. Over a median follow-up of 11.9 months, there were no deaths. These findings suggest that ex vivo perfusion is a valuable technique in pediatric HTx.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":null,"pages":null},"PeriodicalIF":6.4000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Early Single Center Experience with an Ex Vivo Organ Care System in Pediatric Heart Transplantation.\",\"authors\":\"Cathlyn K Medina, Berk Aykut, Lauren E Parker, Neel K Prabhu, Lillian Kang, Ziv Beckerman, Jacob N Schroder, Douglas M Overbey, Joseph W Turek\",\"doi\":\"10.1016/j.healun.2024.10.027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pediatric heart transplantation (HTx) faces challenges such as limited donor availability and the need for complex reconstructions, particularly in patients with congenital anomalies. Ex vivo perfusion offers a promising approach to minimize graft ischemic time and potentially expand the donor pool. We report our single-center experience using the TransMedics Organ Care System (OCS) for ex vivo perfusion in pediatric HTx. From 2020-2024, eight pediatric patients received OCS-perfused donor hearts. Median recipient age was 13 years (range 9-18), and median weight was 58.8 kg (33.2-127.8). Indications for HTx included dilated cardiomyopathy (n=4), hypertrophic cardiomyopathy (n=1), graft vasculopathy (n=1), and Fontan failure (n=2). Median OCS time was 273 minutes (195-328), and recipient ischemic time was 85 minutes (64-139). Post-transplant, all patients had normal LV function at discharge. Over a median follow-up of 11.9 months, there were no deaths. These findings suggest that ex vivo perfusion is a valuable technique in pediatric HTx.</p>\",\"PeriodicalId\":15900,\"journal\":{\"name\":\"Journal of Heart and Lung Transplantation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.4000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Heart and Lung Transplantation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.healun.2024.10.027\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heart and Lung Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.healun.2024.10.027","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Early Single Center Experience with an Ex Vivo Organ Care System in Pediatric Heart Transplantation.
Pediatric heart transplantation (HTx) faces challenges such as limited donor availability and the need for complex reconstructions, particularly in patients with congenital anomalies. Ex vivo perfusion offers a promising approach to minimize graft ischemic time and potentially expand the donor pool. We report our single-center experience using the TransMedics Organ Care System (OCS) for ex vivo perfusion in pediatric HTx. From 2020-2024, eight pediatric patients received OCS-perfused donor hearts. Median recipient age was 13 years (range 9-18), and median weight was 58.8 kg (33.2-127.8). Indications for HTx included dilated cardiomyopathy (n=4), hypertrophic cardiomyopathy (n=1), graft vasculopathy (n=1), and Fontan failure (n=2). Median OCS time was 273 minutes (195-328), and recipient ischemic time was 85 minutes (64-139). Post-transplant, all patients had normal LV function at discharge. Over a median follow-up of 11.9 months, there were no deaths. These findings suggest that ex vivo perfusion is a valuable technique in pediatric HTx.
期刊介绍：
The Journal of Heart and Lung Transplantation, the official publication of the International Society for Heart and Lung Transplantation, brings readers essential scholarly and timely information in the field of cardio-pulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. Importantly, the journal also serves as a medium of communication of pre-clinical sciences in all these rapidly expanding areas.
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