烟酰胺腺嘌呤单核苷酸微生物工程生产概述。

IF 4.1 2区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of biotechnology Pub Date : 2024-11-02 DOI:10.1016/j.jbiotec.2024.10.014

Boting Li, Xiangfeng Meng, Weifeng Liu

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引用次数: 0

摘要

随着人体逐渐衰老，细胞中的 NAD+ 水平会下降，这已被发现与多种老年相关疾病有关。作为 NAD+ 的前体，NMN 能够有效促进 NAD+ 的合成，且无明显副作用。微生物生产 NMN 有可能降低生产成本，促进其广泛应用。本综述以 NAD+ 的代谢途径为基础，总结了 NMN 生物合成代谢工程策略的最新进展。此外，还讨论了未来优化提高 NMN 产量的前景。

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An overview of engineering microbial production of nicotinamide mononucleotide

As the human body gradually ages, the cellular level of NAD⁺ will decline, which has been found to be related to a variety of age-related diseases. As a precursor of NAD⁺, NMN is able to effectively promote the synthesis of NAD⁺ with no significant side effects. Microbial production of NMN holds the potential to lower the production cost and facilitate its wide application. In this review, based on the metabolic pathway of NAD⁺, we summarize recent advances of metabolic engineering strategies for NMN biosynthesis. An outlook for future optimization to improve NMN production is also discussed.

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来源期刊

Journal of biotechnology 工程技术-生物工程与应用微生物

CiteScore

8.90

自引率

2.40%

发文量

190

审稿时长

45 days

期刊介绍： The Journal of Biotechnology has an open access mirror journal, the Journal of Biotechnology: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal provides a medium for the rapid publication of both full-length articles and short communications on novel and innovative aspects of biotechnology. The Journal will accept papers ranging from genetic or molecular biological positions to those covering biochemical, chemical or bioprocess engineering aspects as well as computer application of new software concepts, provided that in each case the material is directly relevant to biotechnological systems. Papers presenting information of a multidisciplinary nature that would not be suitable for publication in a journal devoted to a single discipline, are particularly welcome.