非小细胞肺癌骨转移的新见解:机制与疗法。

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
International Journal of Biological Sciences Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.7150/ijbs.100960
Man Xue, Li Ma, Pengpeng Zhang, Hui Yang, Zhaoxia Wang
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引用次数: 0

摘要

骨转移是非小细胞肺癌(NSCLC)患者的常见死因,大约 30%-40% 的 NSCLC 患者最终会发生骨转移。骨转移,尤其是骨骼相关事件(SRE)的发生,大大降低了患者的总生存率(OS)和生活质量(QoL)。尽管骨靶向药物(BTAs)已被证明可以减少骨转移 NSCLC 患者的 SREs 并改善 QoL,但这些患者的预后仍然很差。了解骨转移的潜在分子途径对于开发新型治疗方法至关重要。骨转移是一个复杂的多步骤过程,涉及肿瘤细胞与骨微环境之间的相互作用。骨微环境为肿瘤细胞提供了肥沃的土壤,各种信号通路和分泌因子之间的串联也在调控 NSCLC 骨转移的发生和进展中发挥着作用。本文对NSCLC骨转移的过程、调控机制和临床治疗进行了全面综述,希望对临床治疗有所帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New insights into non-small cell lung cancer bone metastasis: mechanisms and therapies.

Bone metastasis is a common cause of death in patients with non-small cell lung cancer (NSCLC), with approximately 30-40% of NSCLC patients eventually developing bone metastases. Bone metastasis, especially the occurrence of skeletal-related events (SREs), significantly reduces overall survival (OS) and quality of life (QoL) in patients. Although bone-targeting agents (BTAs) have been shown to reduce SREs and improve QoL in NSCLC patients with bone metastases, the prognosis for these patients remains poor. Understanding the underlying molecular pathways of bone metastasis is crucial for the development of novel therapeutic approaches. Bone metastasis is a complex, multistep process that involves interactions between tumor cells and the bone microenvironment. The bone microenvironment provides a fertile soil for tumor cells, and crosstalk among various signaling pathways and secreted factors also plays a role in regulating the occurrence and progression of bone metastasis in NSCLC. In this article, we provide a comprehensive review of the process, regulatory mechanisms, and clinical treatment in NSCLC bone metastasis, with the hope of assisting with clinical treatment.

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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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