癌症光疗的新时代:机制与应用。

IF 40.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Yuanwei Wang, Ke Ma, Miaomiao Kang, Dingyuan Yan, Niu Niu, Saisai Yan, Panpan Sun, Luzhi Zhang, Lijie Sun, Dong Wang, Hui Tan, Ben Zhong Tang
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引用次数: 0

摘要

过去几十年来,光疗作为一种实验性选择或法规批准的治疗方法,在众多癌症适应症领域取得了长足进步。其中,纳米级光敏剂光疗因其高效性和安全性,已成为晚期肿瘤治疗的重要候选疗法。尽管基于纳米级光敏剂的光疗法在材料、方法和设备方面取得了相当大的研究进展,但其作用机制并不总是很清楚,这阻碍了它们在癌症治疗中的实际应用。因此,本综述从一个新的角度阐述了各种光疗法的工作机制,包括对细胞、细胞器、器官和组织的损伤和调节作用。此外,本综述还将目前可用的光疗方法分为光动力疗法、光热疗法、光免疫疗法、光气疗法和放射疗法。全面了解各种光疗方法的优劣将有助于癌症光疗新时代的到来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A new era of cancer phototherapy: mechanisms and applications.

The past decades have witnessed great strides in phototherapy as an experimental option or regulation-approved treatment in numerous cancer indications. Of particular interest is nanoscale photosensitizer-based phototherapy, which has been established as a prominent candidate for advanced tumor treatment by virtue of its high efficacy and safety. Despite considerable research progress on materials, methods and devices in nanoscale photosensitizing agent-based phototherapy, their mechanisms of action are not always clear, which impedes their practical application in cancer treatment. Hence, from a new perspective, this review elaborates the working mechanisms, involving impairment and moderation effects, of diverse phototherapies on cells, organelles, organs, and tissues. Furthermore, the most current available phototherapy modalities are categorized as photodynamic, photothermal, photo-immune, photo-gas, and radio therapies in this review. A comprehensive understanding of the inferiority and superiority of various phototherapies will facilitate the advent of a new era of cancer phototherapy.

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来源期刊
Chemical Society Reviews
Chemical Society Reviews 化学-化学综合
CiteScore
80.80
自引率
1.10%
发文量
345
审稿时长
6.0 months
期刊介绍: Chemical Society Reviews is published by: Royal Society of Chemistry. Focus: Review articles on topics of current interest in chemistry; Predecessors: Quarterly Reviews, Chemical Society (1947–1971); Current title: Since 1971; Impact factor: 60.615 (2021); Themed issues: Occasional themed issues on new and emerging areas of research in the chemical sciences
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