胃肠癌非编码 RNA 修饰的最新进展。

IF 5.7 2区 医学 Q1 Medicine
Cancer Science Pub Date : 2024-11-01 DOI:10.1111/cas.16380
Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Sarah Rennie, Ken Ofusa, Yuichiro Doki, Hidetoshi Eguchi, Toru Kitagawa, Hideshi Ishii
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引用次数: 0

摘要

阐明癌症发展和增殖的内在机制对于开发彻底治愈癌症的治疗方法非常重要。特别是,需要为难治性胃肠道癌症确定早期检测的诊断标志物和新的治疗策略。癌细胞中会出现各种异常现象,如基因组突变导致的蛋白质功能变化,以及表观遗传调控失调导致的基因表达变化。不编码蛋白质的非编码 RNA(ncRNA)也不例外。最近的报告显示,微小核糖核酸(miRNA)、长非编码核糖核酸(lncRNA)和环状核糖核酸(circRNA)与癌症的进展有密切关系。这些 ncRNA 作为基因表达调控分子备受关注。近来技术的进步使我们不仅能读取 DNA 和 RNA 序列,还能研究每个碱基的修饰状态。特别是,许多研究小组对 N6-甲基腺苷(m6A)进行了全面分析,多项研究报告称,特定基因的 m6A 修饰与癌症进展有关。在此基础上,本综述探讨了 ncRNA 修饰与结直肠癌和胰腺癌等胃肠道癌症的进展有何关系。我们还讨论了据报道具有药物开发潜力的针对 m6A 修饰的酶抑制剂。通过利用 ncRNA 修饰的新视角,我们或许能积累癌症分子生物学方面的知识,并通过诊断和治疗为人类健康做出贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent advances in noncoding RNA modifications of gastrointestinal cancer.

Elucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic methods for the complete cure of cancer. In particular, the identification of diagnostic markers for early detection and new therapeutic strategies for refractory gastrointestinal cancers are needed. Various abnormal phenomena occur in cancer cells, such as functional changes of proteins, led by genomic mutations, and changes in gene expression due to dysregulation of epigenetic regulation. This is no exception for noncoding RNA (ncRNA), which do not encode proteins. Recent reports have revealed that microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) are deeply involved in cancer progression. These ncRNAs have attracted attention as gene expression regulatory molecules. Recent advances in technology have made it possible not only to read DNA and RNA sequences but also to study the modification state of each base. In particular, comprehensive analysis of N6-methyladenosine (m6A) has been performed by many research groups, with multiple studies reporting that m6A modifications of specific genes are associated with cancer progression. Based on the above, this review examines how ncRNA modifications are related to cancer progression in gastrointestinal cancers such as colorectal and pancreatic cancer. We also discuss enzyme inhibitors that have been reported to have drug discovery potential targeting m6A modifications. By utilizing the new perspective of ncRNA modification, we may be able to accumulate knowledge on the molecular biology of cancer and contribute to human health through diagnosis and treatment.

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来源期刊
Cancer Science
Cancer Science ONCOLOGY-
CiteScore
9.90
自引率
3.50%
发文量
406
审稿时长
17 weeks
期刊介绍: Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.
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