Naif Alghamdi, Fahad Alshehri, Sultan Alhazza, Fahad Bhutto, Azhari Alhassan, Mohammed Kechrid, Dhafer Alshehri, Kadi Alshammari, Talal Assiri, Ohoud Assiri, Emad Darewsh, Mohammed Ali, Ruba Qadri, Yasser Alahmadi
{"title":"一名克罗恩病患者因英夫利西单抗治疗引发的急性肾小管间质性肾炎:病例报告。","authors":"Naif Alghamdi, Fahad Alshehri, Sultan Alhazza, Fahad Bhutto, Azhari Alhassan, Mohammed Kechrid, Dhafer Alshehri, Kadi Alshammari, Talal Assiri, Ohoud Assiri, Emad Darewsh, Mohammed Ali, Ruba Qadri, Yasser Alahmadi","doi":"10.1007/s13730-024-00943-6","DOIUrl":null,"url":null,"abstract":"<p><p>We report the case of a 39-year-old man who presented with a history of generalized fatigue, nausea, subjective fever with rigors, and renal dysfunction after receiving infliximab (IFX) therapy for Crohn's disease. A renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After other causes of acute kidney injury were excluded, steroid therapy was initiated, his fever subsided, and kidney function improved. From this case report, infliximab could be a rare cause of elevated kidney function and that it should be not considered a completely safe treatment or disregarded as potential cause of ATIN.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn's disease: a case report.\",\"authors\":\"Naif Alghamdi, Fahad Alshehri, Sultan Alhazza, Fahad Bhutto, Azhari Alhassan, Mohammed Kechrid, Dhafer Alshehri, Kadi Alshammari, Talal Assiri, Ohoud Assiri, Emad Darewsh, Mohammed Ali, Ruba Qadri, Yasser Alahmadi\",\"doi\":\"10.1007/s13730-024-00943-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We report the case of a 39-year-old man who presented with a history of generalized fatigue, nausea, subjective fever with rigors, and renal dysfunction after receiving infliximab (IFX) therapy for Crohn's disease. A renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After other causes of acute kidney injury were excluded, steroid therapy was initiated, his fever subsided, and kidney function improved. From this case report, infliximab could be a rare cause of elevated kidney function and that it should be not considered a completely safe treatment or disregarded as potential cause of ATIN.</p>\",\"PeriodicalId\":9697,\"journal\":{\"name\":\"CEN Case Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-11-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"CEN Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13730-024-00943-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"CEN Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13730-024-00943-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn's disease: a case report.
We report the case of a 39-year-old man who presented with a history of generalized fatigue, nausea, subjective fever with rigors, and renal dysfunction after receiving infliximab (IFX) therapy for Crohn's disease. A renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After other causes of acute kidney injury were excluded, steroid therapy was initiated, his fever subsided, and kidney function improved. From this case report, infliximab could be a rare cause of elevated kidney function and that it should be not considered a completely safe treatment or disregarded as potential cause of ATIN.
期刊介绍:
Clinical and Experimental Nephrology (CEN) Case Reports is a peer-reviewed online-only journal, officially published biannually by the Japanese Society of Nephrology (JSN). The journal publishes original case reports in nephrology and related areas. The purpose of CEN Case Reports is to provide clinicians and researchers with a forum in which to disseminate their personal experience to a wide readership and to review interesting cases encountered by colleagues all over the world, from whom contributions are welcomed.