探索揭示酒精诱发女性不孕的分子机制--一种合理的方法

IF 2.6 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Reproductive Sciences Pub Date : 2024-12-01 Epub Date: 2024-11-01 DOI:10.1007/s43032-024-01692-8
Natasha Sura Anak Lubau, Neevashini Chengebroyen, Vetriselvan Subramaniyan
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引用次数: 0

摘要

本研究旨在探讨长期饮酒对女性不孕症产生影响的分子机制,并强调其重要的社会意义。通过进行全面的文献综述,我们研究了长期饮酒与女性生殖健康之间关系的现有证据。通过对电子数据库和主要期刊的系统检索,我们确定了相关研究。我们综合了受饮酒影响的分子途径方面的信息,特别强调了氧化应激、炎症和荷尔蒙紊乱。此外,我们还回顾了为解决酒精相关健康问题所做的努力,包括公共卫生干预、监管措施和教育倡议。我们的研究发现了强有力的证据,证明长期饮酒与全球死亡率上升和一系列可预防疾病有关。酒精的影响超出了生理后果,还造成了心理、社会和经济负担。长期饮酒会破坏荷尔蒙平衡和生殖功能,导致女性不孕。未来的研究应侧重于量化与饮酒相关的死亡风险,了解与酒精相关的健康后果的性别特异性模式,以及阐明女性不孕症的分子机制。缩小这些差距将为减轻酒精引起的健康问题的负担和促进整体健康提供参考。不同利益相关者之间的合作对于推进研究议程和将研究结果转化为有效的干预措施至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of Uncovering Molecular Mechanisms of Alcohol-Induced Female Infertility-A Rational Approach.

This study aimed to investigate the molecular mechanisms by which chronic alcohol consumption impacts female infertility, highlighting significant societal implications. By conducting a comprehensive literature review, we examined existing evidence on the association between long-term alcohol use and female reproductive health. Relevant studies were identified through systematic searches of electronic databases and key journals. We synthesized information on the molecular pathways affected by alcohol consumption, with particular emphasis on oxidative stress, inflammation, and hormonal disruptions. Additionally, we reviewed efforts to address alcohol-related health issues, including public health interventions, regulatory measures, and educational initiatives. Our study found strong evidence linking chronic alcohol consumption to increased mortality rates and a range of preventable diseases globally. Alcohol's effects extend beyond physiological consequences to psychological, social, and economic burdens. Chronic alcohol consumption disrupts hormonal balance and reproductive function, contributing to female infertility. Future research should focus on quantifying mortality risks associated with alcohol consumption, understanding gender-specific patterns in alcohol-related health outcomes, and elucidating the molecular mechanisms underlying female infertility. Addressing these gaps will inform strategies to mitigate the burden of alcohol-induced health issues and promote overall well-being. Collaborative efforts among diverse stakeholders are essential for advancing research agendas and translating findings into effective interventions.

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来源期刊
Reproductive Sciences
Reproductive Sciences 医学-妇产科学
CiteScore
5.50
自引率
3.40%
发文量
322
审稿时长
4-8 weeks
期刊介绍: Reproductive Sciences (RS) is a peer-reviewed, monthly journal publishing original research and reviews in obstetrics and gynecology. RS is multi-disciplinary and includes research in basic reproductive biology and medicine, maternal-fetal medicine, obstetrics, gynecology, reproductive endocrinology, urogynecology, fertility/infertility, embryology, gynecologic/reproductive oncology, developmental biology, stem cell research, molecular/cellular biology and other related fields.
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