Zehao Cai, Zukai Yang, Ying Wang, Ye Li, Hong Zhao, Hanwen Zhao, Xue Yang, Can Wang, Tengteng Meng, Xiao Tong, Hao Zheng, Zhaoyong He, Chunli Niu, Junzhi Yang, Feng Chen, Zhi Yang, Zhige Zou, Wenbin Li
{"title":"肿瘤治疗诱导场：胶质母细胞瘤患者的新治疗方案。","authors":"Zehao Cai, Zukai Yang, Ying Wang, Ye Li, Hong Zhao, Hanwen Zhao, Xue Yang, Can Wang, Tengteng Meng, Xiao Tong, Hao Zheng, Zhaoyong He, Chunli Niu, Junzhi Yang, Feng Chen, Zhi Yang, Zhige Zou, Wenbin Li","doi":"10.3389/fneur.2024.1413236","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Currently, a range of electromagnetic therapies, including magnetic field therapy, micro-currents therapy, and tumor treating fields, are under investigation for their potential in central nervous system tumor research. Each of these electromagnetic therapies possesses distinct effects and limitations. Our focus is on overcoming these limitations by developing a novel electric field generator. This generator operates by producing alternating induced currents within the tumor area through electromagnetic induction.</p><p><strong>Methods: </strong>Finite element analysis was employed to calculate the distribution of electric fields. Cell viability was assessed using the CCK-8 assay. Tumor volumes and weights served as indicators to evaluate the effectiveness of TTIF. The <i>in-vivo</i> imaging system was utilized to confirm tumor growth in the brains of mice.</p><p><strong>Results: </strong>TTIF significantly inhibited the proliferation of U87 cells both <i>in vitro</i> and <i>in vivo</i>.</p><p><strong>Conclusion: </strong>TTIF significantly inhibited the proliferation of U87 cells both <i>in vitro</i> and <i>in vivo</i>. Consequently, TTIF emerges as a potential treatment option for patients with progressive or metastatic GBM.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1413236"},"PeriodicalIF":2.7000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524832/pdf/","citationCount":"0","resultStr":"{\"title\":\"Tumor treating induced fields: a new treatment option for patients with glioblastoma.\",\"authors\":\"Zehao Cai, Zukai Yang, Ying Wang, Ye Li, Hong Zhao, Hanwen Zhao, Xue Yang, Can Wang, Tengteng Meng, Xiao Tong, Hao Zheng, Zhaoyong He, Chunli Niu, Junzhi Yang, Feng Chen, Zhi Yang, Zhige Zou, Wenbin Li\",\"doi\":\"10.3389/fneur.2024.1413236\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Currently, a range of electromagnetic therapies, including magnetic field therapy, micro-currents therapy, and tumor treating fields, are under investigation for their potential in central nervous system tumor research. Each of these electromagnetic therapies possesses distinct effects and limitations. Our focus is on overcoming these limitations by developing a novel electric field generator. This generator operates by producing alternating induced currents within the tumor area through electromagnetic induction.</p><p><strong>Methods: </strong>Finite element analysis was employed to calculate the distribution of electric fields. Cell viability was assessed using the CCK-8 assay. Tumor volumes and weights served as indicators to evaluate the effectiveness of TTIF. The <i>in-vivo</i> imaging system was utilized to confirm tumor growth in the brains of mice.</p><p><strong>Results: </strong>TTIF significantly inhibited the proliferation of U87 cells both <i>in vitro</i> and <i>in vivo</i>.</p><p><strong>Conclusion: </strong>TTIF significantly inhibited the proliferation of U87 cells both <i>in vitro</i> and <i>in vivo</i>. Consequently, TTIF emerges as a potential treatment option for patients with progressive or metastatic GBM.</p>\",\"PeriodicalId\":12575,\"journal\":{\"name\":\"Frontiers in Neurology\",\"volume\":\"15 \",\"pages\":\"1413236\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524832/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Neurology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fneur.2024.1413236\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fneur.2024.1413236","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Tumor treating induced fields: a new treatment option for patients with glioblastoma.
Purpose: Currently, a range of electromagnetic therapies, including magnetic field therapy, micro-currents therapy, and tumor treating fields, are under investigation for their potential in central nervous system tumor research. Each of these electromagnetic therapies possesses distinct effects and limitations. Our focus is on overcoming these limitations by developing a novel electric field generator. This generator operates by producing alternating induced currents within the tumor area through electromagnetic induction.
Methods: Finite element analysis was employed to calculate the distribution of electric fields. Cell viability was assessed using the CCK-8 assay. Tumor volumes and weights served as indicators to evaluate the effectiveness of TTIF. The in-vivo imaging system was utilized to confirm tumor growth in the brains of mice.
Results: TTIF significantly inhibited the proliferation of U87 cells both in vitro and in vivo.
Conclusion: TTIF significantly inhibited the proliferation of U87 cells both in vitro and in vivo. Consequently, TTIF emerges as a potential treatment option for patients with progressive or metastatic GBM.
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The section Stroke aims to quickly and accurately publish important experimental, translational and clinical studies, and reviews that contribute to the knowledge of stroke, its causes, manifestations, diagnosis, and management.
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