胶质母细胞瘤和高级别胶质瘤的 PET 示踪剂最新进展及其对治疗学的影响。

IF 3 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Jiaqiong Wang MD, PhD , Aldo Serafini MD , Russ Kuker MD , Cyrus Ayubcha MSc , Gary Cohen MD , Helen Nadel MD , Alexander McKinney MD , Abass Alavi MD, PhD , Jian Q. Yu MD
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引用次数: 0

摘要

磁共振成像是目前用于胶质母细胞瘤诊断和治疗后评估的主要成像模式。最近,几种创新的 PET 放射性示踪剂被用于评估胶质母细胞瘤(GBM)。这些放射性示踪剂针对肿瘤中的几个生化和病理生理过程。这些过程包括葡萄糖代谢、DNA 合成和细胞增殖、氨基酸转运、细胞膜生物合成、特异性膜抗原(如前列腺特异性膜抗原)、成纤维细胞活化蛋白抑制剂、转运蛋白和缺氧传感剂,以及针对特异性细胞受体抗原的抗体。本综述旨在讨论这些 PET 放射性药物在评估和治疗 GBM 方面的临床价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The State-of-the-Art PET Tracers in Glioblastoma and High-grade Gliomas and Implications for Theranostics
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来源期刊
PET Clinics
PET Clinics RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
5.70
自引率
3.80%
发文量
78
期刊介绍: As the clinical applications of positron emission tomography (PET) increase, the new PET Clinics brings together the combined expertise of leading authorities in the field to provide you incisive clinical reviews on advances in the use of PET and combined PET/CT. Published quarterly, PET Clinics provides concise, practical guidance on the clinical issues you face every day. It examines PET is effectiveness in cancer diagnosis and staging, as well as exploring PET is usefulness in the areas of dementia, myocardial viability, and other conditions. Full-color images featured throughout. Topics covered include Breast Cancer, Alzheimer is Disease and Dementia, Lymphoma, Lung Cancer, Cardiology, Pediatric Applications, Infection and Inflammation.
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