颅骨测量和头骨形态如何影响帕金森病深部脑刺激手术中的眼下核靶点协调？

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

World neurosurgery Pub Date : 2025-02-01 DOI:10.1016/j.wneu.2024.10.095

Tuan Anh Pham , Cuong Minh Luong , Phuong Duy Dao , Nghia Thanh Vo , Tai Ngoc Tran , Thuy Anh Diem Nguyen

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引用次数: 0

摘要

目的：探讨DBS手术中颅骨测量、颅骨形态与丘脑下核（STN）靶标坐标的相关性。方法：我们对在越南胡志明市Nguyen Tri Phuong医院和大学医学中心接受双侧STN-DBS手术的77例帕金森病患者进行了回顾性研究。采用Pearson相关和多元线性回归分析颅骨测量值和STN目标坐标。根据颅骨形态学指标，包括头侧指数和颅顶不对称指数，比较同一患者两个半球的STN坐标。结果：在颅骨测量中观察到显著的性别差异，男性表现出更大的尺寸。STN坐标与各种颅骨测量结果相关，尤其是x坐标与水平弧度和第三脑室宽度相关性最强（r = 0.4和r = 0.42）。线性回归方程：X (mm) = 0.967 + 0.202∗第三脑室宽度(mm) + 0.024∗水平弧（mm）， R2 = 0.32。颅骨形态学显示影响STN坐标的潜在不对称性。结论：颅测量和第三脑室宽度与STN坐标，尤其是x坐标有显著相关性。我们的研究强调了在DBS手术计划中个体化颅测量的重要性，以优化电极放置和治疗结果。

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How Do Craniometric Measurements and Skull Morphology Influence Subthalamic Nucleus Target Coordinations in Deep Brain Stimulation Surgery for Parkinson Disease?

Objective

This study investigates the correlation among craniometric measurements, skull morphology, and subthalamic nucleus (STN) target coordinates in DBS surgery.

Methods

We conducted a retrospective study of 77 Parkinson disease patients who underwent bilateral STN-DBS surgery at Nguyen Tri Phuong Hospital and University Medical Center in Ho Chi Minh City, Vietnam. Craniometric measurements and STN target coordinates were analyzed using Pearson correlation and multivariate linear regression. The coordinates of the STN were compared between 2 hemispheres in the same patient, based on skull morphology indices, including the Cephalic Index and the Cranial Vault Asymmetry Index.

Results

Significant gender-based differences were observed in craniometric measurements, with males exhibiting larger dimensions. STN coordinates demonstrated correlations with various cranial measurements, notably with X-coordinates correlating most strongly with horizontal arc and third ventricle width (r = 0.4 and r = 0.42, respectively). The linear regression equation: X (mm) = 0.967 + 0.202∗ Third ventricle width (mm) + 0.024∗Horizontal arc (mm) with R2 = 0.32. Skull morphology revealed potential asymmetries affecting STN coordinates.

Conclusions

Craniometric measurements and third ventricle width correlate significantly with STN coordinates, particularly the X-coordinates. Our study highlights the importance of individualized craniometric considerations in DBS surgery planning to optimize electrode placement and therapeutic outcomes.

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来源期刊

World neurosurgery CLINICAL NEUROLOGY-SURGERY

CiteScore

3.90

自引率

15.00%

发文量

1765

审稿时长

47 days

期刊介绍： World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS