西尼罗河病毒感染实验为肠道神经病的康复提供了借鉴。

IF 13.3 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of Clinical Investigation Pub Date : 2024-11-01 DOI:10.1172/JCI185865

Joel C Bornstein

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引用次数: 0

摘要

肠道神经元缺失导致长期胃肠道功能障碍是许多疾病的共同特征，而功能恢复的途径尚不清楚。在本期 JCI 杂志上，Janova 等人报告说，西尼罗河病毒通过 CD4+ 和 CD8+ T 细胞通过穿孔素和 Fas 配体途径杀死肠神经元和神经胶质细胞。肠神经胶质细胞促进了神经发生，至少部分替代了受影响的神经元。虽然神经发生对恢复很重要，但运动障碍和网络结构破坏依然存在。肠道损伤后，神经发生的贡献以及支持肠道神经回路功能恢复的条件仍有待进一步研究。

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Experimental West Nile virus infection provides lessons for recovery from enteric neuropathies.

Loss of enteric neurons leading to long-term gastrointestinal dysfunction is common to many diseases, and the path to functional recovery is unclear. In this issue of the JCI, Janova et al. report that West Nile virus killed enteric neurons and glia via CD4+ and CD8+ T cells acting through the perforin and Fas ligand pathways. Enteric glial cells contributed to neurogenesis and at least partial replacement of affected neurons. While neurogenesis is important for recovery, dysmotility and disruptions to the network structure persisted. Following enteric injury, the contribution of neurogenesis and the conditions that support restoration of enteric neural circuits for functional recovery remain for further investigation.

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来源期刊

Journal of Clinical Investigation 医学-医学：研究与实验

CiteScore

24.50

自引率

1.30%

发文量

1034

审稿时长

2 months

期刊介绍： The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.