{"title":"从菲律宾佛兰芒根中提取的一种罕见的前酰化异黄酮醌。","authors":"Sheng-Li Niu, Xiao-Zhuo Han, Yan-Ping Wang, Jia-Hui Hao, Fei Mo, Can-Can Cui, Ying-Yu Wang, Lu-Yao Zhang, Ya-Ting Sun","doi":"10.1080/10286020.2024.2421918","DOIUrl":null,"url":null,"abstract":"<p><p>In order to make more rational use of <i>Flemingia Philippinensis</i>, a systematic separation from the roots of <i>F. philippinensis</i> was performed in the current study. The investigation of chemical constituents resulted in the isolation of a rare prenylated isoflavone-quinone, fleminquinone A (<b>1</b>), together with four known analogues (<b>2-5</b>). Their structures were established by extensive physical and spectroscopic data analysis. Anti-inflammatory activities of the isolated compounds were evaluated in lipopolysaccharide induced mouse mononuclear macrophage leukemia cells RAW 264.7 model. Compound <b>1</b> exhibited significant inhibitory effects on LPS-induced NO production and COX-2. Compound <b>1</b> also significantly affected the levels of inflammatory cytokines.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A rare prenylated isoflavone-quinone from the roots of <i>Flemingia philippinensis</i>.\",\"authors\":\"Sheng-Li Niu, Xiao-Zhuo Han, Yan-Ping Wang, Jia-Hui Hao, Fei Mo, Can-Can Cui, Ying-Yu Wang, Lu-Yao Zhang, Ya-Ting Sun\",\"doi\":\"10.1080/10286020.2024.2421918\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In order to make more rational use of <i>Flemingia Philippinensis</i>, a systematic separation from the roots of <i>F. philippinensis</i> was performed in the current study. The investigation of chemical constituents resulted in the isolation of a rare prenylated isoflavone-quinone, fleminquinone A (<b>1</b>), together with four known analogues (<b>2-5</b>). Their structures were established by extensive physical and spectroscopic data analysis. Anti-inflammatory activities of the isolated compounds were evaluated in lipopolysaccharide induced mouse mononuclear macrophage leukemia cells RAW 264.7 model. Compound <b>1</b> exhibited significant inhibitory effects on LPS-induced NO production and COX-2. Compound <b>1</b> also significantly affected the levels of inflammatory cytokines.</p>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":\" \",\"pages\":\"1-8\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10286020.2024.2421918\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2024.2421918","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
摘要
为了更合理地利用菲律宾佛兰芒，本研究对菲律宾佛兰芒的根部进行了系统分离。通过对化学成分的研究，分离出了一种罕见的前炔基异黄酮醌，即 Fleminquinone A（1），以及四种已知的类似物（2-5）。通过大量的物理和光谱数据分析，确定了它们的结构。在脂多糖诱导的小鼠单核巨噬细胞白血病细胞 RAW 264.7 模型中评估了分离化合物的抗炎活性。化合物 1 对 LPS 诱导的 NO 生成和 COX-2 具有明显的抑制作用。化合物 1 还能明显影响炎性细胞因子的水平。
A rare prenylated isoflavone-quinone from the roots of Flemingia philippinensis.
In order to make more rational use of Flemingia Philippinensis, a systematic separation from the roots of F. philippinensis was performed in the current study. The investigation of chemical constituents resulted in the isolation of a rare prenylated isoflavone-quinone, fleminquinone A (1), together with four known analogues (2-5). Their structures were established by extensive physical and spectroscopic data analysis. Anti-inflammatory activities of the isolated compounds were evaluated in lipopolysaccharide induced mouse mononuclear macrophage leukemia cells RAW 264.7 model. Compound 1 exhibited significant inhibitory effects on LPS-induced NO production and COX-2. Compound 1 also significantly affected the levels of inflammatory cytokines.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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