个性化 mRNA 癌症疫苗的免疫原性和疗效。

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2024-11-01 DOI:10.1158/2159-8290.CD-24-1196

Pedro Berraondo, Raquel Cuesta, Miguel F Sanmamed, Ignacio Melero

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引用次数: 0

摘要

在本期杂志中，Gainor及其同事报告了个性化新抗原编码mRNA疫苗的免疫原性，这种疫苗能在肿瘤已切除的患者中引起可测量的多功能CD8+和CD4+T细胞反应。在一项 1 期临床试验（NCT03313778）中，4 名 NSCLC 患者术后单独接种了疫苗，12 名黑色素瘤患者接种了他们的个性化疫苗和 pembrolizumab，证实了他们与 20% 至 30% 的预测 MHC-I 和 MHC-II 表位的反应。参见 Gainor 等人的相关文章，第 2209 页。

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Immunogenicity and Efficacy of Personalized Adjuvant mRNA Cancer Vaccines.

In this issue, Gainor and colleagues report on the immunogenicity of personalized neoantigen-encoding mRNA vaccines that elicit measurable polyfunctional CD8+ and CD4+ T-cell responses in patients whose tumors have been resected. Reactivity is substantiated to 20% to 30% of the predicted MHC-I and MHC-II epitopes in four patients with NSCLC postsurgically treated with the vaccine alone and in 12 patients with melanoma treated with their individualized vaccines plus pembrolizumab in the context of a phase 1 clinical trial (NCT03313778). See related article by Gainor et al., p. 2209.

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.