构建癌症标志的全器官宏观视图

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2024-11-01 DOI:10.1158/2159-8290.CD-24-0833

Suling Liu, Yuan Wang, Jiawen Feng, Zhihua Liu, Shengtao Zhou

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引用次数: 0

摘要

尽管在分子或原子分辨率上对癌症特征的了解越来越详细，但大多数研究都不足以调查癌症与人体的系统性相互作用。我们建议从全器官的宏观视角研究癌症的特征，讨论临床前和临床研究中研究癌症的跨器官调控所面临的挑战以及克服这些挑战的潜在方向，并展望如何将这种整体观转化为更有效的疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Building an Organ-Wide Macroscopic View of Cancer Hallmarks.

Despite an increasingly detailed understanding of cancer hallmarks at molecular or atomic resolution, most studies, however, fall short of investigating the systemic interactions of cancer with the human body. We propose to investigate the hallmarks of cancer from an organ-wide macroscopic view, discuss the challenges in preclinical and clinical research to study the cross-organ regulation of cancer together with potential directions to overcome these challenges, and foresee how this holistic view may be translated into more effective therapies.

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.