在伴有或不伴有帕金森病的大疱性类天疱疮患者中通过皮肤活检检测磷酸化α-突触核蛋白

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2024-10-31 DOI:10.1002/mds.30045

Shan Cao, Xiang Fang, Jianwen Wang, Yonghu Sun, Furen Zhang

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引用次数: 0

摘要

背景：在帕金森病（PD）中观察到皮肤磷酸化α-突触核蛋白（P-SYN）的高阳性率。大疱性类天疱疮（BP）是与帕金森病相关的最常见的自身免疫性皮肤病之一：我们的目的是研究大疱性丘疹性荨麻疹患者是否可能成为筛查皮肤 P-SYN 的目标风险人群：方法：通过免疫组化评估伴/不伴PD的BP患者的皮肤P-SYN表达：结果：共招募了22名患有PD的BP患者、24名未患有PD的BP患者和7名健康供体。P-SYN和PGP9.5在所有BP患者中都有共定位，但只有一名健康对照者，而有PD的BP患者比无PD的BP患者有更高的表达（平均值±标准差，10.7±6.7 vs. 7.3±3.2；P = 0.027）。阳性表达主要出现在基底膜区和真皮层：这些结果表明，BP 患者可能是皮肤 P-SYN 筛查的目标风险人群，有助于早期发现 PD。© 2024 The Author(s).运动障碍》由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版。

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Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients of Bullous Pemphigoid with or without Parkinson's Disease.

Background: High positivity rate of skin phosphorylated α-synuclein (P-SYN) was observed in Parkinson's disease (PD). Bullous pemphigoid (BP) is one of the most common autoimmune skin diseases associated with PD.

Objectives: Our aim was to investigate whether BP patients might be a targeted risk population for the screening of skin P-SYN.

Methods: Skin P-SYN expression was evaluated by immunohistochemistry in BP patients with/without PD.

Results: Twenty-two BP patients with PD, 24 BP patients without PD, and seven healthy donors were enrolled. Colocalization of P-SYN and PGP9.5 was found in all BP patients, but only one healthy control, whereas BP patients with PD showed higher expression than BP patients without PD (mean ± standard deviation, 10.7 ± 6.7 vs. 7.3 ± 3.2; P = 0.027). Positive expression was mainly observed in basement membrane zone and dermis.

Conclusion: These results indicated BP patients might be a targeted risk population for the screening of skin P-SYN, which was helpful for the detection of PD early. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.