在伊朗德黑兰诊断中心就诊的嗜酸性粒细胞过多症患者中强直性脊柱炎和弓形虫血清流行率

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2024-11-01 DOI:10.1016/j.cegh.2024.101826

Zohre Fakhrieh- Kashan , Eshrat Beigom Kia , Mohammad Taghi Haghi Ashtiani , Seyed Reza Dabaghi , Mohammad Amin Sari , Enayat Darabi

{"title":"在伊朗德黑兰诊断中心就诊的嗜酸性粒细胞过多症患者中强直性脊柱炎和弓形虫血清流行率","authors":"Zohre Fakhrieh- Kashan , Eshrat Beigom Kia , Mohammad Taghi Haghi Ashtiani , Seyed Reza Dabaghi , Mohammad Amin Sari , Enayat Darabi","doi":"10.1016/j.cegh.2024.101826","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Hypereosinophilia is characterized by an increase in eosinophil levels above the normal range. Secondary hypereosinophilia is frequently seen in helminth infections and allergic conditions. If not diagnosed and managed promptly, eosinophilia can result in various complications impacting health. The aim of this study was to explore the seroprevalence of <em>Strongyloides stercoralis</em> and <em>Toxocara</em> spp. among hypereosinophilic patients undergoing evaluation at selected diagnostic centers in Tehran<strong>.</strong></div></div><div><h3>Methods</h3><div>A comprehensive questionnaire was completed, and a blood sample was collected from each participant. The seropositivity of helminth infections was ascertained through indirect enzyme-linked immunosorbent assay (ELISA) employing commercially procured kits for discerning anti-<em>S. stercoralis</em> and anti-<em>Toxocara</em> spp. IgG antibodies. Statistical analysis was conducted using SPSS 21 software.</div></div><div><h3>Results</h3><div>Of the 135 participants in this study, 61 (45.2 %) were male and 74 (54.8 %) were female. The seropositivity rates for strongyloidiasis and toxocariasis were found to be 9.6 % and 0.74 %, respectively. Among the various underlying medical conditions observed in the participants, Type 2 Diabetes (T2D) was the most prevalent, and it showed a significant association with seropositivity for strongyloidiasis (p < 0.05).</div></div><div><h3>Conclusion</h3><div>The seropositivity for <em>S. stercoralis</em> was higher than that for <em>Toxocara</em> spp.. The significant association between seropositivity for <em>S. stercoralis</em> and diabetes underscores the importance of conducting community-based studies and implementing screening initiatives targeting high-risk populations to assess the seroprevalence of strongyloidiasis.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"30 ","pages":"Article 101826"},"PeriodicalIF":2.3000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in Tehran, Iran\",\"authors\":\"Zohre Fakhrieh- Kashan , Eshrat Beigom Kia , Mohammad Taghi Haghi Ashtiani , Seyed Reza Dabaghi , Mohammad Amin Sari , Enayat Darabi\",\"doi\":\"10.1016/j.cegh.2024.101826\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Hypereosinophilia is characterized by an increase in eosinophil levels above the normal range. Secondary hypereosinophilia is frequently seen in helminth infections and allergic conditions. If not diagnosed and managed promptly, eosinophilia can result in various complications impacting health. The aim of this study was to explore the seroprevalence of <em>Strongyloides stercoralis</em> and <em>Toxocara</em> spp. among hypereosinophilic patients undergoing evaluation at selected diagnostic centers in Tehran<strong>.</strong></div></div><div><h3>Methods</h3><div>A comprehensive questionnaire was completed, and a blood sample was collected from each participant. The seropositivity of helminth infections was ascertained through indirect enzyme-linked immunosorbent assay (ELISA) employing commercially procured kits for discerning anti-<em>S. stercoralis</em> and anti-<em>Toxocara</em> spp. IgG antibodies. Statistical analysis was conducted using SPSS 21 software.</div></div><div><h3>Results</h3><div>Of the 135 participants in this study, 61 (45.2 %) were male and 74 (54.8 %) were female. The seropositivity rates for strongyloidiasis and toxocariasis were found to be 9.6 % and 0.74 %, respectively. Among the various underlying medical conditions observed in the participants, Type 2 Diabetes (T2D) was the most prevalent, and it showed a significant association with seropositivity for strongyloidiasis (p < 0.05).</div></div><div><h3>Conclusion</h3><div>The seropositivity for <em>S. stercoralis</em> was higher than that for <em>Toxocara</em> spp.. The significant association between seropositivity for <em>S. stercoralis</em> and diabetes underscores the importance of conducting community-based studies and implementing screening initiatives targeting high-risk populations to assess the seroprevalence of strongyloidiasis.</div></div>\",\"PeriodicalId\":46404,\"journal\":{\"name\":\"Clinical Epidemiology and Global Health\",\"volume\":\"30 \",\"pages\":\"Article 101826\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Epidemiology and Global Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213398424003233\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Epidemiology and Global Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213398424003233","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

摘要

背景嗜酸性粒细胞过多症的特征是嗜酸性粒细胞水平升高超过正常范围。继发性嗜酸性粒细胞过多症常见于蠕虫感染和过敏性疾病。如果不及时诊断和处理，嗜酸性粒细胞增多症会导致各种影响健康的并发症。本研究旨在探讨在德黑兰选定的诊断中心接受评估的嗜酸性粒细胞增多症患者中盘虫和弓形虫血清阳性率。通过间接酶联免疫吸附试验（ELISA）确定蠕虫感染的血清阳性率，该试验采用市场上购买的试剂盒来检测抗S. stercoralis和抗Toxocara spp.IgG抗体。统计分析采用 SPSS 21 软件进行。强直性脊柱炎和弓形虫血清阳性率分别为 9.6 % 和 0.74 %。结论盘尾丝虫血清阳性率高于弓形虫血清阳性率。盘尾丝虫血清阳性反应与糖尿病之间的明显联系突出表明，开展以社区为基础的研究和实施针对高危人群的筛查措施以评估强直性脊柱炎血清阳性反应的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Seroprevalence of strongyloidiasis and toxocariasis among hypereosinophilic patients seeking care at diagnostic centers in Tehran, Iran

Background

Hypereosinophilia is characterized by an increase in eosinophil levels above the normal range. Secondary hypereosinophilia is frequently seen in helminth infections and allergic conditions. If not diagnosed and managed promptly, eosinophilia can result in various complications impacting health. The aim of this study was to explore the seroprevalence of Strongyloides stercoralis and Toxocara spp. among hypereosinophilic patients undergoing evaluation at selected diagnostic centers in Tehran.

Methods

A comprehensive questionnaire was completed, and a blood sample was collected from each participant. The seropositivity of helminth infections was ascertained through indirect enzyme-linked immunosorbent assay (ELISA) employing commercially procured kits for discerning anti-S. stercoralis and anti-Toxocara spp. IgG antibodies. Statistical analysis was conducted using SPSS 21 software.

Results

Of the 135 participants in this study, 61 (45.2 %) were male and 74 (54.8 %) were female. The seropositivity rates for strongyloidiasis and toxocariasis were found to be 9.6 % and 0.74 %, respectively. Among the various underlying medical conditions observed in the participants, Type 2 Diabetes (T2D) was the most prevalent, and it showed a significant association with seropositivity for strongyloidiasis (p < 0.05).

Conclusion

The seropositivity for S. stercoralis was higher than that for Toxocara spp.. The significant association between seropositivity for S. stercoralis and diabetes underscores the importance of conducting community-based studies and implementing screening initiatives targeting high-risk populations to assess the seroprevalence of strongyloidiasis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.