Yu Hu, Liu-Lin Chen, Zhen Ye, Lin-Zhen Li, Huan-Zhu Qian, Ming-Quan Wu, Juan Wang, Kai-Hua Qin, Qiao-Bo Ye
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The treatment potential of IN for UC has been proven by numerous preclinical and clinical studies in recent years.</p><p><strong>Objective: </strong>This article provides a comprehensive review of the utility and potential of IN in the treatment of UC.</p><p><strong>Methods: </strong>'Indigo naturalis' 'Qing dai' 'Qingdai' 'Ulcerative colitis' and 'UC' are used as the keywords, and the relevant literature is collected from online databases (Elsevier, PubMed, and Web of Science).</p><p><strong>Results and conclusion: </strong>Indirubin, indigo, isatin, tryptanthrin, and β-sitosterol are considered the key components in the treatment of UC with IN. Both preclinical and clinical studies support the efficacy of IN for UC, especially in severe UC or in those who do not respond to or have poor efficacy with existing therapies. The mechanisms of IN for UC are associated with the aryl hydrocarbon receptor pathway activation, immune regulation, oxidative stress inhibition, and intestinal microbial modulation. However, the clinical use of IN has the risks of adverse events such as pulmonary hypertension, which suggests the necessity for its rational application. As a potential therapeutic agent for UC that is currently receiving more attention, the clinical value of IN has been initially demonstrated and warrants further evaluation.</p>","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"62 1","pages":"818-832"},"PeriodicalIF":3.9000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533244/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>Indigo naturalis</i> as a potential drug in the treatment of ulcerative colitis: a comprehensive review of current evidence.\",\"authors\":\"Yu Hu, Liu-Lin Chen, Zhen Ye, Lin-Zhen Li, Huan-Zhu Qian, Ming-Quan Wu, Juan Wang, Kai-Hua Qin, Qiao-Bo Ye\",\"doi\":\"10.1080/13880209.2024.2415652\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>Ulcerative colitis (UC) is an intractable inflammatory bowel disease that threatens the health of patients. 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引用次数: 0
摘要
背景:溃疡性结肠炎(UC)是一种难以治愈的炎症性肠病,威胁着患者的健康。由于治疗策略有限,探索更高效、更安全的药物势在必行。天然蓝靛(IN)是一种传统中药,具有多种药理活性,包括抗炎、抗氧化和免疫调节活性。近年来,大量临床前和临床研究证实了蓝靛果治疗 UC 的潜力:方法:以 "天然靛蓝""青黛""青黛""溃疡性结肠炎 "和 "UC "为关键词,从在线数据库(Elsevier、PubMed 和 Web of Science)中收集相关文献:靛红素、靛蓝、异靛红、色黄素和β-谷甾醇被认为是 IN 治疗 UC 的关键成分。临床前研究和临床研究都支持 IN 对治疗 UC 的疗效,尤其是对严重的 UC 或对现有疗法无反应或疗效不佳的患者。IN 治疗 UC 的机制与芳基烃受体通路激活、免疫调节、氧化应激抑制和肠道微生物调节有关。然而,IN 的临床应用存在肺动脉高压等不良反应的风险,这表明其合理应用的必要性。IN 作为一种潜在的 UC 治疗药物,目前正受到越来越多的关注,其临床价值已得到初步证实,值得进一步评估。
Indigo naturalis as a potential drug in the treatment of ulcerative colitis: a comprehensive review of current evidence.
Context: Ulcerative colitis (UC) is an intractable inflammatory bowel disease that threatens the health of patients. The limited availability of therapeutic strategies makes it imperative to explore more efficient and safer drugs. Indigo naturalis (IN) is a traditional Chinese medicine that possesses many pharmacological activities, including anti-inflammatory, antioxidant, and immunomodulatory activities. The treatment potential of IN for UC has been proven by numerous preclinical and clinical studies in recent years.
Objective: This article provides a comprehensive review of the utility and potential of IN in the treatment of UC.
Methods: 'Indigo naturalis' 'Qing dai' 'Qingdai' 'Ulcerative colitis' and 'UC' are used as the keywords, and the relevant literature is collected from online databases (Elsevier, PubMed, and Web of Science).
Results and conclusion: Indirubin, indigo, isatin, tryptanthrin, and β-sitosterol are considered the key components in the treatment of UC with IN. Both preclinical and clinical studies support the efficacy of IN for UC, especially in severe UC or in those who do not respond to or have poor efficacy with existing therapies. The mechanisms of IN for UC are associated with the aryl hydrocarbon receptor pathway activation, immune regulation, oxidative stress inhibition, and intestinal microbial modulation. However, the clinical use of IN has the risks of adverse events such as pulmonary hypertension, which suggests the necessity for its rational application. As a potential therapeutic agent for UC that is currently receiving more attention, the clinical value of IN has been initially demonstrated and warrants further evaluation.
期刊介绍:
Pharmaceutical Biology will publish manuscripts describing the discovery, methods for discovery, description, analysis characterization, and production/isolation (including sources and surveys) of biologically-active chemicals or other substances, drugs, pharmaceutical products, or preparations utilized in systems of traditional medicine.
Topics may generally encompass any facet of natural product research related to pharmaceutical biology. Papers dealing with agents or topics related to natural product drugs are also appropriate (e.g., semi-synthetic derivatives). Manuscripts will be published as reviews, perspectives, regular research articles, and short communications. The primary criteria for acceptance and publication are scientific rigor and potential to advance the field.