产前接触新烟碱类杀虫剂、胎儿内分泌激素和出生体型：来自 SMBCS 的研究结果

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2024-11-01 DOI:10.1016/j.envint.2024.109111

Boya Zhang , Zheng Wang , Jiming Zhang , Yiming Dai , Jiayun Ding , Xingzu Zhou , Xiaojuan Qi , Chunhua Wu , Zhijun Zhou

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引用次数: 0

摘要

背景据报道，新烟碱类杀虫剂（NNIs）是一种内分泌干扰物，会对人类健康造成不良影响。本研究旨在探讨产前接触 NNIs 对新生儿出生大小和内分泌激素的影响，并评估激素的潜在中介作用。在分娩当天收集的母体尿液样本中检测了12种母体非壬基酚（p-NNIs）和6种非壬基酚的代谢物（m-NNIs），并分析了脐带血清中的5种甲状腺激素和2种性激素。对NNIs及其特定代谢物的浓度进行加总，以确定每一类NNIs的作用。采用广义线性模型和加权量子和回归法研究了产前NNIs暴露对新生儿体型和内分泌激素的影响，并通过中介分析进一步探讨了激素的潜在中介作用。新生儿头围（孕龄 Z 值）的下降与 5-OH-IMI 的 10 倍增长相关（β = -0.15，95 %CI：-0.26，-0.03）、∑DIN（β = -0.22，95 %CI：-0.40，-0.03）、∑IMI（β = -0.20，95 %CI：-0.35，-0.06）和∑NNIs（β = -0.23，95 %CI：-0.42，-0.04）。∑IMI和∑DIN是造成显著负混合物效应的主要因素，没有观察到性别特异性效应。在∑DIN 和 TT3（β = -0.013，95 %CI：-0.025，-0.002）、∑IMI 和 T（β = -0.035，95 %CI：-0.065，-0.004）之间分别观察到负相关。此外，TT3 和 T 对产前∑DIN 和∑IMI 暴露与头围的负相关分别有 6.7% 和 6.1% 的中介效应。内分泌激素可能部分介导了这些关联。

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Prenatal exposure to neonicotinoid insecticides, fetal endocrine hormones and birth size: Findings from SMBCS

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Prenatal exposure to neonicotinoid insecticides, fetal endocrine hormones and birth size: Findings from SMBCS

Background

Neonicotinoid insecticides (NNIs) were reported to be endocrine disruptors and cause adverse health effects in human. However, epidemiological evidence about the effect of prenatal NNIs exposure on birth outcome and hormones remains limited.

Objectives

This study aimed to explore the effects of prenatal NNIs exposure on neonatal birth size and endocrine hormones, and assess the potential mediating role of hormones.

Methods

The study included 860 mother–child pairs from the Sheyang Mini Birth Cohort Study. 12 parent NNIs (p-NNIs) and 6 metabolites of NNIs (m-NNIs) were measured in maternal urine samples collected on their delivery days, and 5 thyroid hormones and 2 sex hormones were analyzed in cord serum. The concentrations of p-NNIs and its specific metabolite(s) were summed to characterize the role of each class of NNIs. Generalized linear model and weighted quantile sum regression were used to examine the impact of prenatal NNIs exposure on birth size and endocrine hormones, and potential mediating roles of hormones were further explored using mediation analysis.

Results

Higher detection frequencies of m-NNIs were observed than those in p-NNIs. A decrease in neonatal head circumference for gestation age z-score was associated with a 10-fold increase in 5-OH-IMI (β = -0.15, 95 %CI: −0.26, −0.03), ∑DIN (β = -0.22, 95 %CI: −0.40, −0.03), ∑IMI (β = -0.20, 95 %CI: −0.35, −0.06) and ∑NNIs (β = -0.23, 95 %CI: −0.42, −0.04). ∑IMI and ∑DIN were the major contributors to the significantly negative mixture effect and no sex-specific effect was observed. Negative associations were observed between ∑DIN and TT3 (β = -0.013, 95 %CI: −0.025, −0.002), ∑IMI and T (β = -0.035, 95 %CI: −0.065, −0.004), respectively. Furthermore, TT3 and T demonstrated 6.7 % and 6.1 % mediating effects on the negative association of prenatal ∑DIN and ∑IMI exposure with head circumference.

Conclusions

Our findings suggested the potential endocrine disruptive properties of NNIs and their impacts on head circumference. Endocrine hormones may partly mediate these associations.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.