William R. Miranda MD , C. Charles Jain MD , Heidi M. Connolly MD , Alexander Van De Bruaene MD , Gruschen R. Veldtman MBChB , Alexander C. Egbe MD
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引用次数: 0
摘要
我们假设，结合静息外周静脉压（PVP）和 N 端前脑钠尿肽（NT-proBNP）对患者进行表型分析可预测有创方坦血流动力学。因此，根据 PVP 和 NT-proBNP 值将 35 名有 Fontan 缓解术史的成人分为三组：正常、↑NT-proBNP（≥300 pg/dL）或↑PVP（≥15 mm Hg）和↑PVP+↑NT-proBNP。正常值组患者的静息肺动脉楔压和丰坦压普遍正常，只有一名患者的运动值异常；相反，↑PVP+↑NT-proBNP 组所有患者的静息丰坦压或肺动脉楔压均升高，↑NT-proBNP 或 ↑PVP 组为中间组。
Peripheral Venous Pressure And NT-proBNP Phenotypes as Surrogates for Invasive Fontan Haemodynamics in Adults
We hypothesized that phenotyping patients using a combination of resting peripheral venous pressure (PVP) and N-terminal pro–brain natriuretic peptide (NT-proBNP) would predict invasive Fontan haemodynamics. Accordingly, 35 adults with a history of Fontan palliation were categorized into 3 groups according to PVP and NT-proBNP values: normal, ↑NT-proBNP (≥300 pg/dL) or ↑PVP (≥15 mm Hg), and ↑PVP+↑NT-proBNP. Those in the normal values group universally had normal resting pulmonary artery wedge and Fontan pressures, with a single patient having abnormal exercise values; conversely, all patients in the ↑PVP+↑NT-proBNP group had increased resting Fontan or pulmonary artery wedge pressures, with those in the ↑NT-proBNP or ↑PVP group constituting an intermediate group.
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