探索马齿苋多糖的治疗潜力：植物化学和免疫调节作用综述

IF 2.4 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Carbohydrate Research Pub Date : 2024-10-23 DOI:10.1016/j.carres.2024.109298

Hai-Xin Liu , Ling-Ling Ding , Yan-Yan Chen , Shi-Yuan Wen

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引用次数: 0

摘要

马齿苋（Portulaca oleracea L.）是一种既可食用又可药用的植物，在民间医药中历来以其利尿、解热、防腐、解痉和驱虫功能而受到重视。欧芹多糖（POP）是一种重要的生物活性成分，具有多种生物活性。值得注意的是，其免疫调节功能已成为一个重要的研究领域。人们对 POP 的提取、纯化、单糖组成、结构特征和生物活性进行了广泛研究，以确定其活性成分，阐明其药理作用和潜在的分子机制。本综述旨在阐明与这些多糖相关的药理机制和分子途径，从而强调其治疗前景和营养意义。此外，这篇综述还批判性地审视了持久性有机污染物目前的研究状况，找出了差距，并提出了创新观点，以丰富围绕这些生物活性化合物的科学讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Exploring the therapeutic potential of polysaccharide from Portulaca oleracea L.: A review of phytochemistry and immunomodulatory effect

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Exploring the therapeutic potential of polysaccharide from Portulaca oleracea L.: A review of phytochemistry and immunomodulatory effect

Portulaca oleracea L., a plant with both edible and medicinal properties, is traditionally valued for its diuretic, antipyretic, antiseptic, antispasmodic, and anthelmintic functions in folk medicine. P. oleracea polysaccharide (POP), a pivotal bioactive component, has various biological activities. Notably, their immunomodulatory capabilities have emerged as a significant area of research. The extraction, purification, monosaccharide composition, structure characterization, and biological activity of POP have been extensively investigated to identify the active components and to clarify their pharmacological actions and underlying molecular mechanisms. It aims to delineate the pharmacological mechanisms and molecular pathways associated with these polysaccharides, thereby underscoring their therapeutic promise and nutritional significance. Furthermore, the review critically examines the current research landscape of POP, identifying gaps and proposing innovative perspectives to enrich the scientific discourse surrounding these bioactive compounds.

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来源期刊

Carbohydrate Research 化学-生化与分子生物学

CiteScore

5.00

自引率

3.20%

发文量

183

审稿时长

3.6 weeks

期刊介绍： Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".