残留/复发性鼻咽癌和鼻咽淋巴瘤：基于表观弥散系数和 18F-FDG PET/MRI 标准化摄取值的双参数区分

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Medical Imaging and Radiation Sciences Pub Date : 2024-10-01 DOI:10.1016/j.jmir.2024.101482

Dr Hong Qu , Dr Yuping Zeng , Miss Huiyu Chen , Dr Lifeng Hang , Dr Jizhuang Wang , Dr Hong Li , Dr Guihua Jiang

{"title":"残留/复发性鼻咽癌和鼻咽淋巴瘤：基于表观弥散系数和 18F-FDG PET/MRI 标准化摄取值的双参数区分","authors":"Dr Hong Qu , Dr Yuping Zeng , Miss Huiyu Chen , Dr Lifeng Hang , Dr Jizhuang Wang , Dr Hong Li , Dr Guihua Jiang","doi":"10.1016/j.jmir.2024.101482","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the multi-parametric diagnostic performance with apparent diffusion coefficient (ADC), standardized uptake value (SUV) and the relative SUV (rSUV) of hybrid <sup>18</sup>F-fluoro-2-deoxy-D-glucose positron emission tomography/magnetic resonance image (<sup>18</sup>F-FDG PET/MRI) to differentiate residual/recurrent nasopharyngeal carcinoma (RNPC) and nasopharyngeal lymphoma (NPL).</div></div><div><h3>Materials and Methods</h3><div>One hundred and sixty-three patients, including PNPCs (<em>n</em> = 86), RNPCs (<em>n</em> = 53) and PNPLs (<em>n</em> = 24), were recruited in this study. The peak standardized uptake value (SUV<sub>peak</sub>), maximum (SUV<sub>max</sub>), and mean (SUV<sub>mean</sub>) were obtained by workstation, and relative SUV<sub>peak</sub> (rSUV<sub>peak</sub>), SUV<sub>max</sub> (rSUV<sub>max</sub>) and SUV<sub>mean</sub> (rSUV<sub>mean</sub>) were obtained by standardization of the contralateral normal-appearing lateral pterygoid muscle. The minimum apparent diffusion coefficient (ADC<sub>min</sub>) and mean ADC (ADC<sub>mean</sub>) were obtained by ROIs measurement. Bivariate logistic regression was used to determine the best logistic regression model for classification. The area under the curve (AUC) was used to evaluate the diagnostic performance.</div></div><div><h3>Results</h3><div>RNPCs showed significantly lower SUV<sub>mean</sub>, rSUV<sub>peak</sub>, rSUV<sub>max</sub> and rSUV<sub>mean</sub> than that of NPLs. The ADC<sub>mean</sub> of PNPL was significantly lower than that of RNPC. The joint model with ADC<sub>mean</sub> and rSUV<sub>mean</sub> achieved the higher AUC, which was 0.92, and the sensitivity and specificity were 88.7% and 91.7%, respectively.</div></div><div><h3>Conclusion</h3><div>The combination of ADC<sub>mean</sub> and rSUV<sub>mean</sub> allowed reliable differentiation between RNPC and NPL.</div></div>","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Residual/recurrent nasopharyngeal carcinoma and nasopharyngeal lymphoma: Dual-parameters differentiation based on apparent diffusion coefficient and standardized uptake value of 18F-FDG PET/MRI\",\"authors\":\"Dr Hong Qu , Dr Yuping Zeng , Miss Huiyu Chen , Dr Lifeng Hang , Dr Jizhuang Wang , Dr Hong Li , Dr Guihua Jiang\",\"doi\":\"10.1016/j.jmir.2024.101482\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>To evaluate the multi-parametric diagnostic performance with apparent diffusion coefficient (ADC), standardized uptake value (SUV) and the relative SUV (rSUV) of hybrid <sup>18</sup>F-fluoro-2-deoxy-D-glucose positron emission tomography/magnetic resonance image (<sup>18</sup>F-FDG PET/MRI) to differentiate residual/recurrent nasopharyngeal carcinoma (RNPC) and nasopharyngeal lymphoma (NPL).</div></div><div><h3>Materials and Methods</h3><div>One hundred and sixty-three patients, including PNPCs (<em>n</em> = 86), RNPCs (<em>n</em> = 53) and PNPLs (<em>n</em> = 24), were recruited in this study. The peak standardized uptake value (SUV<sub>peak</sub>), maximum (SUV<sub>max</sub>), and mean (SUV<sub>mean</sub>) were obtained by workstation, and relative SUV<sub>peak</sub> (rSUV<sub>peak</sub>), SUV<sub>max</sub> (rSUV<sub>max</sub>) and SUV<sub>mean</sub> (rSUV<sub>mean</sub>) were obtained by standardization of the contralateral normal-appearing lateral pterygoid muscle. The minimum apparent diffusion coefficient (ADC<sub>min</sub>) and mean ADC (ADC<sub>mean</sub>) were obtained by ROIs measurement. Bivariate logistic regression was used to determine the best logistic regression model for classification. The area under the curve (AUC) was used to evaluate the diagnostic performance.</div></div><div><h3>Results</h3><div>RNPCs showed significantly lower SUV<sub>mean</sub>, rSUV<sub>peak</sub>, rSUV<sub>max</sub> and rSUV<sub>mean</sub> than that of NPLs. The ADC<sub>mean</sub> of PNPL was significantly lower than that of RNPC. The joint model with ADC<sub>mean</sub> and rSUV<sub>mean</sub> achieved the higher AUC, which was 0.92, and the sensitivity and specificity were 88.7% and 91.7%, respectively.</div></div><div><h3>Conclusion</h3><div>The combination of ADC<sub>mean</sub> and rSUV<sub>mean</sub> allowed reliable differentiation between RNPC and NPL.</div></div>\",\"PeriodicalId\":46420,\"journal\":{\"name\":\"Journal of Medical Imaging and Radiation Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Imaging and Radiation Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1939865424002133\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Imaging and Radiation Sciences","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1939865424002133","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

摘要

目的评价混合 18F- 氟-2-脱氧-D-葡萄糖正电子发射断层扫描/磁共振成像（18F-FDG PET/MRI）的表观弥散系数（ADC）、标准化摄取值（SUV）和相对 SUV（rSUV）的多参数诊断性能，以区分残留/复发性鼻咽癌（RNPC）和鼻咽淋巴瘤（NPL）。材料与方法本研究共招募了 163 例患者，包括鼻咽癌（86 例）、鼻咽癌（53 例）和鼻咽淋巴瘤（24 例）。通过工作站获得峰值标准化摄取值（SUVpeak）、最大值（SUVmax）和平均值（SUVmean），通过标准化对侧正常外观的翼外侧肌获得相对SUVpeak（rSUVpeak）、SUVmax（rSUVmax）和SUVmean（rSUVmean）。最小表观弥散系数（ADCmin）和平均 ADC（ADCmean）通过 ROI 测量获得。双变量逻辑回归用于确定最佳的逻辑回归分类模型。结果RNPCs的SUVmean、rSUVpeak、rSUVmax和rSUVmean明显低于NPLs。PNPL 的 ADCmean 明显低于 RNPC。ADCmean和rSUVmean联合模型的AUC值较高，为0.92，灵敏度和特异度分别为88.7%和91.7%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Residual/recurrent nasopharyngeal carcinoma and nasopharyngeal lymphoma: Dual-parameters differentiation based on apparent diffusion coefficient and standardized uptake value of 18F-FDG PET/MRI

Objectives

To evaluate the multi-parametric diagnostic performance with apparent diffusion coefficient (ADC), standardized uptake value (SUV) and the relative SUV (rSUV) of hybrid ¹⁸F-fluoro-2-deoxy-D-glucose positron emission tomography/magnetic resonance image (¹⁸F-FDG PET/MRI) to differentiate residual/recurrent nasopharyngeal carcinoma (RNPC) and nasopharyngeal lymphoma (NPL).

Materials and Methods

One hundred and sixty-three patients, including PNPCs (n = 86), RNPCs (n = 53) and PNPLs (n = 24), were recruited in this study. The peak standardized uptake value (SUV_peak), maximum (SUV_max), and mean (SUV_mean) were obtained by workstation, and relative SUV_peak (rSUV_peak), SUV_max (rSUV_max) and SUV_mean (rSUV_mean) were obtained by standardization of the contralateral normal-appearing lateral pterygoid muscle. The minimum apparent diffusion coefficient (ADC_min) and mean ADC (ADC_mean) were obtained by ROIs measurement. Bivariate logistic regression was used to determine the best logistic regression model for classification. The area under the curve (AUC) was used to evaluate the diagnostic performance.

Results

RNPCs showed significantly lower SUV_mean, rSUV_peak, rSUV_max and rSUV_mean than that of NPLs. The ADC_mean of PNPL was significantly lower than that of RNPC. The joint model with ADC_mean and rSUV_mean achieved the higher AUC, which was 0.92, and the sensitivity and specificity were 88.7% and 91.7%, respectively.

Conclusion

The combination of ADC_mean and rSUV_mean allowed reliable differentiation between RNPC and NPL.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Medical Imaging and Radiation Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

2.30

自引率

11.10%

发文量

231

审稿时长

53 days

期刊介绍： Journal of Medical Imaging and Radiation Sciences is the official peer-reviewed journal of the Canadian Association of Medical Radiation Technologists. This journal is published four times a year and is circulated to approximately 11,000 medical radiation technologists, libraries and radiology departments throughout Canada, the United States and overseas. The Journal publishes articles on recent research, new technology and techniques, professional practices, technologists viewpoints as well as relevant book reviews.