致敏图谱中树状成分的聚类提示了过敏原免疫疗法的关键组合

IF 5.8 2区医学 Q1 ALLERGY

Annals of Allergy Asthma & Immunology Pub Date : 2024-10-25 DOI:10.1016/j.anai.2024.08.088

M. Yasniuk , V. Rodinkova , V. Mokin , S. Yuriev , L. DuBuske

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引用次数: 0

摘要

结果 7518 名患者（37.53%）对至少一种树木过敏原敏感。对 Sec c 敏感的患者占大多数（1404 人），其次是对 Cupressus arizonica Cup a 1 敏感的患者（1147 人）。这个群组包括了所有树木相关分子和提取物的一半--13 种（Bet v 6、Bro pa、Cup a 1、Cup s、Fra e、Fra e 1、Jun a、Mor r、Ole e 1、Ole e 9、Pla a 1、Pla a 2、Pla a 3）。黑杨提取物与 Alternaria、狗、猫、马过敏原和梯牧草分子 Phl p 2 聚类。聚类 4 包括所有 PR-10 蛋白质，包括花粉和与食物相关的 Aln g 1、Api g 1、Ara h 8、Bet v 1、Cor a 1.0103、Cor a 1.0401、Cor a_pollen、Dau c、Dau c 1、Fag s 1、Fra a 1+3、Gly m 4 和 Mal d 1。聚类分析显示这些过敏原成分之间关系密切。Bet v 1、Cor a 1.0103 和 Fag s 1 位于一个亚簇中，而 Aln g 1 与 Cor a_pollen 提取物、Mad d 1 和 Cor a 1.0401 的关系最为密切。

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CLUSTERING OF TREE COMPONENTS IN SENSITIZATION PROFILES SUGGESTS KEY COMBINATIONS FOR ALLERGEN IMMUNOTHERAPY

Introduction

Patient sensitization patterns need to be understood to optimize allergen immunotherapy.

Methods

20,033 individuals were tested by ALEX methods in 17 regions of Ukraine in 2020-2022.

Results

7518 patients (37.53 %) were sensitive to at least one tree allergen. Sensitization to Sec c dominated (1404) followed by sensitivity to Cupressus arizonica Cup a 1( 1147). This cluster included half – 13 -of all tree-related molecules and extracts – (Bet v 6, Bro pa, Cup a 1, Cup s, Fra e, Fra e 1, Jun a, Mor r, Ole e 1, Ole e 9, Pla a 1, Pla a 2, Pla a 3). Populus nigra extract was clustered with Alternaria, dog, cat, horse allergens and timothy grass molecule Phl p 2. Cluster 4 comprised all PR-10 proteins including pollen and food associated including Aln g 1, Api g 1, Ara h 8, Bet v 1, Cor a 1.0103, Cor a 1.0401, Cor a_pollen, Dau c, Dau c 1, Fag s 1, Fra a 1+3, Gly m 4 and Mal d 1. Agglomerative clustering showed close relations between these component allergens. Bet v 1, Cor a 1.0103 and Fag s 1 were in one subcluster, while Aln g 1 associated most closely with Cor a_pollen extract and with Mad d 1 and Cor a 1.0401.

Conclusions

Analysis of patterns of sensitization suggests there are groups of allergen components to which tree sensitized patients are most commonly sensitized potentially useful for allergen immunotherapy strategies.

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来源期刊

Annals of Allergy Asthma & Immunology 医学-过敏

CiteScore

6.50

自引率

6.80%

发文量

437

审稿时长

33 days

期刊介绍： Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.