银屑病关节炎患者的肌少症和骨质疏松症：单中心回顾性研究

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Pub Date : 2024-10-10 DOI:10.1016/j.nut.2024.112595

Kenji Takami M.D. , Mari Higashiyama M.D., Ph.D. , Shigeyoshi Tsuji M.D., Ph.D.

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引用次数: 0

摘要

目的炎症性疾病患者出现骨质疏松症和肌肉疏松症的风险很高，但有关银屑病关节炎（PsA）的报道却很少。本研究旨在评估我院 PsA 患者中肌肉疏松症和骨质疏松症的发生率，以及肌肉疏松症与骨质疏松症的关联。结果总体而言，肌少症和弧前肌少症的发生率分别为 5.1%和 16.7%。肌肉疏松症前期和肌肉疏松症组的体重指数（BMI）明显较低。此外，"肌肉疏松症前症 "和 "肌肉疏松症 "组所有区域的T值均明显较低。对各部位 T 评分决定因素的多变量分析表明，腰椎和股骨颈与 SMI 有明显关系，全髋关节与 BMI 和类风湿因子阳性有明显关系。男性和女性的骨质疏松症发生率分别为 5.7% 和 7.5%。SMI、T-score和BMI之间存在显著相关性，临床实践中应加以考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sarcopenia and osteoporosis in patients with psoriatic arthritis: A single-center retrospective study

Objective

The risk of both osteoporosis and sarcopenia is high in inflammatory diseases, but there have been few reports of psoriatic arthritis (PsA). This study aimed to evaluate the rate of sarcopenia and osteoporosis, and the association of sarcopenia with osteoporosis in patients with PsA at our institution.

Methods

The data in this study were extracted from 320 patients with PsA meeting CASPAR criteria diagnosed between January 2010 and December 2021. The 156 patients who had undergone body composition measurements with dual-energy X-ray absorptiometry were included.

Results

Overall, the rate of sarcopenia and presarcopenia were 5.1% and 16.7%. Body mass index (BMI) was significantly lower in the presarcopenia and sarcopenia group. Furthermore, the presarcopenia and sarcopenia group had a significantly lower T-score in all regions. Multivariate analysis of the determinants of T-score for each site showed that SMI was significantly involved for the lumbar spine and the femoral neck, and BMI and rheumatoid factor positivity for the total hip.

Conclusions

In patients with PsA, the rate of sarcopenia was 5.1%. Osteoporosis rates for males and females were 5.7% and 7.5%, respectively. SMI, T-score, and BMI are significantly correlated with each other and should be considered in clinical practice.

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.