对故意自残患者的血液进行定性分析:处方药和检测出的药物之间的差异。

IF 2 Q3 NEUROSCIENCES
Neuropsychopharmacology Reports Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI:10.1002/npr2.12492
Masato Masuda, Brian Waters, Leo Gotoh, Yoshihiko Nakamura, Yoshifumi Kato, Shigeki Nabeshima, Shin-Ichi Kubo, Nobuaki Eto, Hiroaki Kawasaki
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引用次数: 0

摘要

背景:虽然在故意自残(DSH)过程中有时会服用药物,但还没有研究尝试分析DSH患者血液中的药物,并将其与处方药或其他药物进行比较。本研究分析了自残患者血液中的药物,并记录了检测到的药物、处方药物和可疑药物:方法:在 2021 年 4 月至 2022 年 9 月期间,患有 DSH 并转入福冈大学医院急诊室的患者参与研究。精神科医生对患者的信息进行了评估,如精神科治疗史和最近的DSH方法,以及入院后1个月内的处方药物。血液样本采用 LC-MS/MS 进行分析。根据患者是否在一个月内服用过精神药物将其分为几组:55名患者参加了研究。其中 40 人在入院后 1 个月内服用过精神药物。然而,在 55 名参与者中,有 42 人(76%)被检测出服用了非处方药物(NPD)。在药物和非处方药过量的患者中,非处方药物的检出率明显较高(p = 0.036),但在使用其他方法的患者(n = 14)和没有处方药物的患者(n = 10)中也检出了非处方药物:讨论:这是第一项重点针对从事 DSH 的患者血液进行药物分析的研究。本研究中约有 80% 的 DSH 患者服用过 NPD,这表明处方药物与血液中检测到的药物之间存在很大差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Qualitative analysis of blood from patients engaging in deliberate self-harm: Differences between prescribed and detected drugs.

Background: While drugs are sometimes taken during deliberate self-harm (DSH), no study has attempted to analyze drugs in the blood of DSH patients and compare them with prescribed medications or other drugs. In this study, drugs were analyzed from the blood of DSH patients, and the detected, prescribed, and suspected drugs were documented.

Methods: Patients who practiced DSH and were transferred to the emergency sites of Fukuoka University Hospital between April 2021 and September 2022 participated in the study. Psychiatrists assessed information such as the history of psychiatric treatment and recent methods of DSH, as well as prescribed drugs within 1 month of presenting to the hospital. Blood samples were analyzed using LC-MS/MS. Participants were divided into groups according to whether or not they were prescribed psychotropics within 1 month.

Results: Fifty-five patients were enrolled in the study. Forty had been prescribed psychotropics within 1 month of hospital admission. However, non-prescribed drugs (NPD) were detected in 42 of the 55 participants (76%). The detection of NPD was significantly high among patients with overdose of medications and OTC drugs (p = 0.036), but NPD were also detected in patients who engaged in other methods (n = 14), and in patients without prescribed medication (n = 10).

Discussion: This is the first study focused on the drug analysis of blood from patients engaging in DSH. Approximately 80% of the DSH patients in this study had taken NPD, revealing a large discrepancy between prescribed medications and those detected in the blood.

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来源期刊
Neuropsychopharmacology Reports
Neuropsychopharmacology Reports Psychology-Clinical Psychology
CiteScore
3.60
自引率
4.00%
发文量
75
审稿时长
14 weeks
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