18F]FDG PET/CT 在治疗滤泡细胞源性甲状腺癌中的作用。

IF 3.5 2区医学 Q2 ONCOLOGY

Cancer Imaging Pub Date : 2024-10-28 DOI:10.1186/s40644-024-00791-8

Klaudia Zajkowska, Paulina Cegla, Marek Dedecjus

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引用次数: 0

摘要

滤泡细胞源性甲状腺癌占甲状腺恶性肿瘤的大多数。这组异质性肿瘤包括分化良好型、分化不良型和未分化型，它们具有不同的病理特征、临床表现和预后。2-[18F]氟-2-脱氧-D-葡萄糖正电子发射断层扫描结合计算机断层扫描（[18F]FDG PET/CT）是一种用于肿瘤患者常规临床实践的成像模式。[18F]FDG正电子发射计算机断层扫描已成为一种有价值的工具，可用于识别临床疗效不佳的高风险患者，并促进个体化临床决策。本综述旨在总结[18F]FDG PET/CT在滤泡细胞源性甲状腺癌的初诊、治疗和随访中的作用，并考虑到分化程度。详细讨论了一些有争议的问题，包括甲状腺中意外检测到的[18F]FDG摄取的意义、[18F]FDG PET/CT在早期评估分子靶向疗法反应中的作用及其预后价值。

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Role of [¹⁸F]FDG PET/CT in the management of follicular cell-derived thyroid carcinoma.

Follicular cell-derived thyroid carcinomas constitute the majority of thyroid malignancies. This heterogeneous group of tumours includes well differentiated, poorly differentiated, and undifferentiated forms, which have distinct pathological features, clinical behaviour, and prognosis. Positron emission tomography with 2-[¹⁸F]fluoro-2-deoxy-D-glucose combined with computed tomography ([¹⁸F]FDG PET/CT) is an imaging modality used in routine clinical practice for oncological patients. [¹⁸F]FDG PET/CT has emerged as a valuable tool for identifying patients at high risk of poor clinical outcomes and for facilitating individualized clinical decision-making. The aim of this comprehensive review is to summarize current knowledge regarding the role of [¹⁸F]FDG PET/CT in primary diagnosis, treatment, and follow-up of follicular cell-derived thyroid carcinomas considering the degree of differentiation. Controversial issues, including significance of accidentally detected [¹⁸F]FDG uptake in the thyroid, the role of [¹⁸F]FDG PET/CT in the early assessment of response to molecular targeted therapies, and its prognostic value are discussed in detail.

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来源期刊

Cancer Imaging ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

7.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cancer Imaging is an open access, peer-reviewed journal publishing original articles, reviews and editorials written by expert international radiologists working in oncology. The journal encompasses CT, MR, PET, ultrasound, radionuclide and multimodal imaging in all kinds of malignant tumours, plus new developments, techniques and innovations. Topics of interest include: Breast Imaging Chest Complications of treatment Ear, Nose & Throat Gastrointestinal Hepatobiliary & Pancreatic Imaging biomarkers Interventional Lymphoma Measurement of tumour response Molecular functional imaging Musculoskeletal Neuro oncology Nuclear Medicine Paediatric.