针对衰老肿瘤微环境的免疫治疗策略。

IF 6.4 1区医学 Q1 ONCOLOGY

British Journal of Cancer Pub Date : 2024-10-28 DOI:10.1038/s41416-024-02865-7

Tadahito Yasuda, Y Alan Wang

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引用次数: 0

摘要

衰老细胞既可以促进免疫抑制性肿瘤微环境，也可以促进免疫监视。尽管癌症免疫疗法产生了革命性的影响，但对实体瘤，尤其是晚期实体瘤的持久反应仍然有限。最近的研究揭示了肿瘤微环境（TME）中的衰老状态对治疗耐受性的影响，而克服这些挑战需要付出巨大的努力。本综述总结了靶向细胞衰老的最新进展，尤其关注针对细胞衰老特征的免疫调节方法。

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Immune therapeutic strategies for the senescent tumor microenvironment.

Senescent cells can either to promote immunosuppressive tumor microenvironment or facilitate immune surveillance. Despite the revolutionary impact of cancer immunotherapy, durable responses in solid tumors, particularly in advanced stages, remain limited. Recent studies have shed light on the influence of senescent status within the tumor microenvironment (TME) on therapy resistance and major efforts are needed to overcome these challenges. This review summarizes recent advancements in targeting cellular senescence, with a particular focus on immunomodulatory approaches on the hallmarks of cellular senescence.

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来源期刊

British Journal of Cancer 医学-肿瘤学

CiteScore

15.10

自引率

1.10%

发文量

383

审稿时长

6 months

期刊介绍： The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.