Serdar Öter, Ali Özkömeç, Mehmet Buğra Bozan, Fatih Mehmet Yazar, İlhami Taner Kale, Ayşe Azak Bozan, Ali İşler
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The aim of this study was to determine whether immature granulocyte IGC and DNI values measured in preoperative blood parameters have a diagnostic benefit for the detection of advanced colon cancer.</p><p><strong>Methods: </strong>A study was conducted on patients who had undergone selective operation for colon cancer in our clinic from February 2015 to February 2020. The patients were divided into two groups: early stage (stage I-III) and advanced stage (stage IV) colon cancer. The IGC and DNI values as well as other hematological parameters, demographic parameters (sex, age) in these two groups were compared.</p><p><strong>Results: </strong>A total of 43 patients with mean age 67.47 (35-96) years were included in the study. Eighteen of the patients were male and 25 were female. When the early stage and advanced stage colon cancer groups were compared, no statistically significant difference was found between age, sex, white blood cell count, lymphocyte-to-monocyte ratio, eosinophil count, basophil count, mean platelet volume and: systemic immune-inflammation index score. It was observed that platelet-to-lymphocyte ratio, IGC and DNI or Immature Granulocyte Percentage (IGP) values were statistically significantly higher in the metastatic colon cancer group compared to the non-metastatic group. When the specificity and sensitivity of laboratory markers in metastatic colon cancer were examined, it was observed that the specificity and sensitivity of DNI or IGP and IGC were statistically higher than other values.</p><p><strong>Conclusions: </strong>DNI, IGC and PLR values, which are the parameters measured in the preoperative period are easily measurable laboratory parameters and do not involve additional costs in differentiating metastatic from non-metastatic colon cancer in the preoperative period.</p>","PeriodicalId":8210,"journal":{"name":"Annali italiani di chirurgia","volume":"95 5","pages":"825-831"},"PeriodicalIF":0.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Preoperative Delta Neutrophil Index, Platelet Lymphocyte Ratio and Immature Granulocyte Count for Differentiating Metastatic Colon Cancer from Non-Metastatic Colon Cancer: A Retrospective Study.\",\"authors\":\"Serdar Öter, Ali Özkömeç, Mehmet Buğra Bozan, Fatih Mehmet Yazar, İlhami Taner Kale, Ayşe Azak Bozan, Ali İşler\",\"doi\":\"10.62713/aic.3811\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>Immature granulocytes show bone marrow activation before neutrophil response and there are studies in the literature showing that the number of immature granulocytes is an auxiliary marker in the diagnosis and treatment of different diseases. The Delta Neutrophil Index (DNI), Immature Granulocyte Count (IGC) have previously been studied as markers in thyroid and breast cancers. The aim of this study was to determine whether immature granulocyte IGC and DNI values measured in preoperative blood parameters have a diagnostic benefit for the detection of advanced colon cancer.</p><p><strong>Methods: </strong>A study was conducted on patients who had undergone selective operation for colon cancer in our clinic from February 2015 to February 2020. The patients were divided into two groups: early stage (stage I-III) and advanced stage (stage IV) colon cancer. The IGC and DNI values as well as other hematological parameters, demographic parameters (sex, age) in these two groups were compared.</p><p><strong>Results: </strong>A total of 43 patients with mean age 67.47 (35-96) years were included in the study. Eighteen of the patients were male and 25 were female. When the early stage and advanced stage colon cancer groups were compared, no statistically significant difference was found between age, sex, white blood cell count, lymphocyte-to-monocyte ratio, eosinophil count, basophil count, mean platelet volume and: systemic immune-inflammation index score. It was observed that platelet-to-lymphocyte ratio, IGC and DNI or Immature Granulocyte Percentage (IGP) values were statistically significantly higher in the metastatic colon cancer group compared to the non-metastatic group. 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引用次数: 0
摘要
目的：未成熟粒细胞显示中性粒细胞反应前的骨髓活化，有文献研究表明，未成熟粒细胞数量是诊断和治疗不同疾病的辅助标记。以前曾有研究将德尔塔中性粒细胞指数（DNI）和未成熟粒细胞计数（IGC）作为甲状腺癌和乳腺癌的标志物。本研究旨在确定术前血液参数中测量的未成熟粒细胞 IGC 和 DNI 值是否对检测晚期结肠癌有诊断作用：研究对象为2015年2月至2020年2月在我院接受选择性结肠癌手术的患者。患者分为两组：早期结肠癌（I-III 期）和晚期结肠癌（IV 期）。比较两组患者的 IGC 和 DNI 值以及其他血液学参数、人口统计学参数（性别、年龄）：研究共纳入 43 名患者，平均年龄为 67.47（35-96）岁。其中男性患者 18 人，女性患者 25 人。比较早期结肠癌组和晚期结肠癌组的年龄、性别、白细胞计数、淋巴细胞与单核细胞比率、嗜酸性粒细胞计数、嗜碱性粒细胞计数、平均血小板体积和全身免疫炎症指数评分，均未发现有统计学意义的差异。据观察，与非转移组相比，转移性结肠癌组的血小板-淋巴细胞比值、IGC 和 DNI 或未成熟粒细胞百分比 (IGP) 值在统计学上明显更高。在对转移性结肠癌实验室标记物的特异性和敏感性进行研究时，发现DNI或IGP和IGC的特异性和敏感性在统计学上高于其他值：结论：术前检测的 DNI、IGC 和 PLR 值是很容易测量的实验室指标，在术前区分转移性和非转移性结肠癌时不会产生额外费用。
Preoperative Delta Neutrophil Index, Platelet Lymphocyte Ratio and Immature Granulocyte Count for Differentiating Metastatic Colon Cancer from Non-Metastatic Colon Cancer: A Retrospective Study.
Aim: Immature granulocytes show bone marrow activation before neutrophil response and there are studies in the literature showing that the number of immature granulocytes is an auxiliary marker in the diagnosis and treatment of different diseases. The Delta Neutrophil Index (DNI), Immature Granulocyte Count (IGC) have previously been studied as markers in thyroid and breast cancers. The aim of this study was to determine whether immature granulocyte IGC and DNI values measured in preoperative blood parameters have a diagnostic benefit for the detection of advanced colon cancer.
Methods: A study was conducted on patients who had undergone selective operation for colon cancer in our clinic from February 2015 to February 2020. The patients were divided into two groups: early stage (stage I-III) and advanced stage (stage IV) colon cancer. The IGC and DNI values as well as other hematological parameters, demographic parameters (sex, age) in these two groups were compared.
Results: A total of 43 patients with mean age 67.47 (35-96) years were included in the study. Eighteen of the patients were male and 25 were female. When the early stage and advanced stage colon cancer groups were compared, no statistically significant difference was found between age, sex, white blood cell count, lymphocyte-to-monocyte ratio, eosinophil count, basophil count, mean platelet volume and: systemic immune-inflammation index score. It was observed that platelet-to-lymphocyte ratio, IGC and DNI or Immature Granulocyte Percentage (IGP) values were statistically significantly higher in the metastatic colon cancer group compared to the non-metastatic group. When the specificity and sensitivity of laboratory markers in metastatic colon cancer were examined, it was observed that the specificity and sensitivity of DNI or IGP and IGC were statistically higher than other values.
Conclusions: DNI, IGC and PLR values, which are the parameters measured in the preoperative period are easily measurable laboratory parameters and do not involve additional costs in differentiating metastatic from non-metastatic colon cancer in the preoperative period.
期刊介绍：
Annali Italiani di Chirurgia is a bimonthly journal and covers all aspects of surgery:elective, emergency and experimental surgery, as well as problems involving technology, teaching, organization and forensic medicine. The articles are published in Italian or English, though English is preferred because it facilitates the international diffusion of the journal (v.Guidelines for Authors and Norme per gli Autori). The articles published are divided into three main sections:editorials, original articles, and case reports and innovations.
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