表观遗传老化的因果推理

IF 39.1 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2024-10-29 DOI:10.1038/s41576-024-00799-7

Kejun Ying

引用次数: 0

摘要

在这篇 "贸易工具"（Tools of the Trade）文章中，Kejun Ying介绍了全表观基因组孟德尔随机化（epigenome-wide Mendelian randomization），该方法将孟德尔随机化与基于DNA甲基化的表观遗传时钟相结合，以鉴定与寿命和健康寿命有潜在因果关系的CpG位点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Causal inference for epigenetic ageing

查看原文本刊更多论文

Causal inference for epigenetic ageing

In this Tools of the Trade article, Kejun Ying describes epigenome-wide Mendelian randomization, which integrates Mendelian randomization into a DNA-methylation-based epigenetic clock to identify CpG sites with potential causal links to lifespan and healthspan.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

期刊介绍： At Nature Reviews Genetics, our goal is to be the leading source of reviews and commentaries for the scientific communities we serve. We are dedicated to publishing authoritative articles that are easily accessible to our readers. We believe in enhancing our articles with clear and understandable figures, tables, and other display items. Our aim is to provide an unparalleled service to authors, referees, and readers, and we are committed to maximizing the usefulness and impact of each article we publish. Within our journal, we publish a range of content including Research Highlights, Comments, Reviews, and Perspectives that are relevant to geneticists and genomicists. With our broad scope, we ensure that the articles we publish reach the widest possible audience. As part of the Nature Reviews portfolio of journals, we strive to uphold the high standards and reputation associated with this esteemed collection of publications.